ArticleJournal of autism and developmental disorders2019
Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts.
Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Factor associated with the occurrence of epilepsy in autism: a systematic review.Journal of autism and developmental disorders · 2023Pooled it
- Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022Pooled it
- Defining and Measuring Developmental Regression During Childhood: A Scoping Review.Autism research : official journal of the International Society for Autism Research · 2026Article
- Adult Clinical Outcomes, Diagnostic Loss and Predictors in Individuals Diagnosed With Autism in Childhood.Journal of autism and developmental disorders · 2026Article
- Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population-Based Birth Cohort Study.Autism research : official journal of the International Society for Autism Research · 2025Article
- Towards an agreed approach to investigate children with developmental regression.BMJ paediatrics open · 2025Article
- Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study.Autism research : official journal of the International Society for Autism Research · 2025Article
- Phenotypic characteristics and rehabilitation effect of children with regressive autism spectrum disorder: a prospective cohort study.BMC psychiatry · 2024Article
- The Role ofInternational journal of molecular sciences · 2023Article
- Autistic clinical profiles, age at first concern, and diagnosis among children with autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Autism under the umbrella of ESSENCE.Frontiers in psychiatry · 2023Article
- A Multi-Center Study on the Relationship Between Developmental Regression and Disease Severity in Children With Autism Spectrum Disorders.Frontiers in psychiatry · 2022Article
- Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma.Frontiers in psychiatry · 2022Article
- Brief Report: Health-Related Quality of Life in Preschoolers with Autism Spectrum Disorder is Related to Diagnostic Age and Autistic Symptom Severity.Journal of autism and developmental disorders · 2021Article
- Neonatal Imitation, Intersubjectivity, and Children With Atypical Development: Do Observations on Autism and Down Syndrome Change Our Understanding?Frontiers in psychology · 2021Article
- Vaccines and autism: a preliminary qualitative study on the beliefs of concerned mothers in Italy.International journal of qualitative studies on health and well-being · 2020Article
- Article
- Bridging the Gap Between Physical Health and Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Review
- Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.International journal of environmental research and public health · 2019Review
- Is Autism Inborn And Lifelong For Everyone?Neuropsychiatric disease and treatment · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.