ArticleClinical and experimental nephrology2019
Podocyte penetration of the glomerular basement membrane to contact on the mesangial cell at the lesion of mesangial interposition in lupus nephritis: a three-dimensional analysis by serial block-face scanning electron microscopy.
Article in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- vEMRec: High-Resolution Volume Electron Microscopy Reconstruction Based on Structure-Preserving and High-Fidelity 3D Alignment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- vEMINR: Ultra-Fast Isotropic Reconstruction for Volume Electron Microscopy With Implicit Neural Representation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine.Cell and tissue research · 2024Article
- Serial Block Face-Scanning Electron Microscopy as a Burgeoning Technology.Advanced biology · 2023Review
- Recent advances in electron microscopy for the diagnosis and research of glomerular diseases.Kidney research and clinical practice · 2023Article
- Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors.PloS one · 2023Article
- Volume electron microscopy.Nature reviews. Methods primers · 2022Article
- Role of Palatine Tonsil and Epipharyngeal Lymphoid Tissue in the Development of Glomerular Active Lesions (International journal of molecular sciences · 2022Review
- Mesangial Cells in Lupus Nephritis.Current rheumatology reports · 2022Review
- Ultrastructural and phenotypical diversity of macrophages in the rat ileal mucosa.Cell and tissue research · 2021Article
- Complexities of the glomerular basement membrane.Nature reviews. Nephrology · 2021Review
- Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography.Frontiers in cell and developmental biology · 2021Article
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5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe interaction among the glomerular components plays an important role in the development of glomerular lesions; thus, investigation of the ultrastructural three-dimensional (3D) configuration of the human glomerular cells and extracellular matrix (ECM) is important for understanding the pathogenesis of glomerulosclerosis, especially glomerulonephritis.
methodsWe applied a new technique of serial block-face scanning electron microscopy (SBF-SEM), which helps to acquire serial electron microscopic images to reconstruct a 3D ultrastructure, to a human kidney biopsy specimen obtained from a 25-year-old woman with lupus nephritis.
resultsSBF-SEM demonstrated that the cytoplasmic processes of the podocyte penetrated into the lamina densa of the glomerular basement membrane, and was in direct contact with the cytoplasm of mesangial cells at the site of mesangial interposition.
conclusionAlthough this is a single-case observational study, SBF-SEM revealed a unique 3D configuration, suggesting a novel mechanism of direct intercellular cross-communication between podocytes and mesangial cells, aside from the presumed paracrine communication.
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