Evidence map›Paper›PMID 30734130›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C.

Diego Alves Vieira, Luciana Rodrigues da Cunha, Cliviany Borges da Silva, Maria Thereza Bastos Almeida, Adriana Dias Gomes, César Lúcio Lopes de Faria, Rosângela Teixeira, Fernando Silva Neves, Gifone Aguiar Rocha, Fabrício Freire de Melo and 2 more

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Diego Alves VieiraFaculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Luciana Rodrigues da CunhaFaculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Cliviany Borges da SilvaFaculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Maria Thereza Bastos AlmeidaMedical undergraduate student, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Adriana Dias GomesLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
César Lúcio Lopes de FariaLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Rosângela TeixeiraFaculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Fernando Silva NevesSciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Gifone Aguiar RochaLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Fabrício Freire de MeloLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Dulciene Maria de Magalhães QueirozLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Luciana Diniz SilvaFaculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil. lucianadinizsilva@gmail.com.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients.

methods132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations.

resultsMajor depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36-physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.

conclusionThis is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.

Indexed as

FemaleGenotypeHaplotypesHepatitis C, ChronicHumansInterleukin-10Interleukin-6MaleMiddle AgedQuality of LifeInterleukin-10Interleukin-6Chronic hepatitis CHealth-related quality of lifeIL10 gene polymorphismIL6 gene polymorphism

Identifiers

PMID30734130
OpenAlexW2913819329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.