Trial reportInternational journal of biometeorology2019
Evidence for the therapeutic effect of the organic content in Szigetvár thermal water on osteoarthritis: a double-blind, randomized, controlled clinical trial.
Trial report in International journal of biometeorology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Anti-inflammatory Effects of Harkány Medicinal Water
Introducing a New and Validated Placebo Development Method to Healing Water Based Rehabilitation Research
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Evidence-based balneotherapy in Hungary. Updated systematic review and meta-analysis of the Hungarian clinical trials.International journal of biometeorology · 2026Pooled it
- Balneotherapy for osteoarthritis: a systematic review.Rheumatology international · 2023Pooled it
- Pooled it
- A New and Validated, Randomised, Controlled Placebo Water Development Trial for Medicinal Water-based Research.In vivo (Athens, Greece)Trial
- Relevance of balneotherapy for osteoarthritis-a systematic literature review covering the past 5 years.Wiener medizinische Wochenschrift (1946) · 2025Review
- Challenges of blinding in clinical balneology trials: a scoping review.BMC complementary medicine and therapies · 2025Article
- The Effect of Szigetvár Medicinal Water on HaCaT Cells Exposed to Dithranol.Life (Basel, Switzerland) · 2024Article
- Public interest in spa therapy during the COVID-19 pandemic: analysis of Google Trends data among Turkey.International journal of biometeorology · 2021Article
- Peloids as Thermotherapeutic Agents.International journal of environmental research and public health · 2021Article
- A comprehensive analysis to understand the mechanism of action of balneotherapy: why, how, and where they can be used? Evidence from in vitro studies performed on human and animal samples.International journal of biometeorology · 2020Review
- Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds).International journal of biometeorology · 2020Review
- Effects of medicinal waters on the UV-sensitivity of human keratinocytes - a comparative pilot study.International journal of biometeorology · 2019Article
- To treat or not to treat? Misbeliefs in spa water disinfection.International journal of biometeorology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The therapeutic effects of mineral waters have been attributed to the inorganic components alone; however, biologically active organic components are also present. We aimed to investigate whether the healing effect of Szigetvár thermal mineral water could relate to the organic matter in patients suffering from osteoarthritis of the hips and the knees. XAD macroreticular resins were used to prepare the organic fraction. Patients received a 30-min thermal water (34 °C) treatment in a bath tub, five times a week for 3 weeks. After randomization, patients were divided into three groups: tap water, mineral water, and organic fraction group. Primary outcomes were range of movement (ROM), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and visual analog scale (VAS) for pain severity, and the Short Form 36 (SF-36) questionnaire was used. These scores and indices were measured at baseline, after the last treatment, and at the end of the 3-month follow-up period. Seventy-four patients (age 67.3 ± 4.48 years) were enrolled: tap water n = 24, mineral water n = 26, and organic fraction n = 24. Treatment with the redissolved organic fraction significantly improved ROM, WOMAC, and SF-36 scores compared to the tap water. Our clinical trial provided evidence for the beneficial health effects of the organic fraction of Szigetvár medicinal water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.