Observational studyBJS open2019
Role of lymph node yield and lymph node ratio in predicting outcomes in non-metastatic colorectal cancer.
Observational study in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment.Annals of coloproctology · 2024Guideline
- Pooled it
- Inking outside the box: systematic review on the utility of tattooing lesions in rectal cancer.International journal of colorectal disease · 2022Pooled it
- Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study.Annals of gastroenterological surgery · 2026Article
- Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort.Annals of gastroenterological surgery · 2026Article
- Clinical Significance of Lymph Node Count in Colon Cancer Surgery: A Tumour Location-stratified Prognostic Analysis Based on an Integrated Phase-III Randomized Controlled Trial (JCOG2310AS3).Journal of the anus, rectum and colon · 2026Article
- Developing a Clinician-Friendly Online Dynamic Nomogram for Survival Prediction in Colon Cancer Patients.Annals of gastroenterological surgery · 2026Article
- Prognostic and Predictive Value of Lymph Node Ratio in Stage III Colon Cancer in the Era of Molecular Biomarkers.Journal of the anus, rectum and colon · 2026Article
- Article
- Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas.World journal of clinical oncology · 2025Article
- Article
- Impact of self-expandable metallic prosthesis on lymph node dissemination in obstructive left-sided colorectal cancer.Surgical endoscopy · 2025Article
- Mismatch Repair Status and Lymph Node Ratio in Survival Prediction of Stage II/III Rectal Cancer Patients: A Comprehensive Analysis of a Multi-Center Retrospective Study.Cancer medicine · 2025Article
- Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- Lymph node yield does not affect the cancer-specific survival of patients with T1 colorectal cancer: a population-based retrospective study of the U.S. database and a Chinese registry.International journal of colorectal disease · 2025Article
- Diagnostic performance of Node-RADS score for mesorectal lymph node metastasis in rectal cancer.Abdominal radiology (New York) · 2025Article
- Prognostic value of metastatic lymph node ratio and its effect on disease-free survival in colon cancer.Frontiers in oncology · 2025Article
- Clinicopathologic characteristics and predictive nomogram of skip lymph node metastasis in gastric cancer.Frontiers in oncology · 2025Article
- AI-Assisted surgical vision: evaluating YOLOv8 and YOLOv12 for real-time detection in colon cancer surgery.Frontiers in surgery · 2025Article
- Open Versus Laparoscopic Oncological Resections for Colon Cancer: An Experience at an Average-Volume Center.Cureus · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lymph node yield (LNY) of 12 or more in resection of colorectal cancer is recommended in current international guidelines. Although a low LNY (less than 12) is associated with poorer outcome in some studies, its prognostic value is unclear in patients with early-stage colorectal or rectal cancer with a complete pathological response following neoadjuvant therapy. Lymph node ratio (LNR), which reflects the proportion of positive to total nodes obtained, may be more accurate in predicting outcome in stage III colorectal cancer. This study aimed to identify factors correlating with LNY and evaluate the prognostic role of LNY and LNR in colorectal cancer. Methods: An observational study was performed on patients with colorectal cancer treated at three hospitals in Melbourne, Australia, from January 2010 to March 2016. Association of LNY and LNR with clinical variables was analysed using linear regression. Disease-free (DFS) and overall (OS) survival were investigated with Cox regression and Kaplan-Meier survival analyses. Results: Some 1585 resections were analysed. Median follow-up was 27·1 (range 0·1-71) months. Median LNY was 16 (range 0-86), and was lower for rectal cancers, decreased with increasing age, and increased with increasing stage. High LNY (12 or more) was associated with better DFS in colorectal cancer. Subgroup analysis indicated that low LNY was associated with poorer DFS and OS in stage III colonic cancer, but had no effect on DFS and OS in rectal cancer (stages I-III). Higher LNR was predictive of poorer DFS and OS. Conclusion: Low LNY (less than 12) was predictive of poor DFS in stage III colonic cancer, but was not a factor for stage I or II colonic disease or any rectal cancer. LNR was a predictive factor in DFS and OS in stage III colonic cancer, but influenced DFS only in rectal cancer.
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