Evidence map›Paper›PMID 30734015›Full record

ArticleBJS open2019

Breast-conserving surgery

S Sinnadurai, A Kwong, M Hartman, E Y Tan, N T Bhoo-Pathy, M Dahlui, M H See, C H Yip, N A Taib, N Bhoo-Pathy

Abstract readMulticenter Study
In one paragraph

Article in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S SinnaduraiDepartment of Surgery, University Malaya Medical Centre University of Malaya Kuala Lumpur Malaysia.
A KwongDepartment of Surgery University of Hong Kong Pokfulam Hong Kong.
M HartmanDivision of General Surgery (Breast Surgery) National University Hospital Singapore.
E Y TanDepartment of General Surgery Tan Tock Seng Hospital Singapore.
N T Bhoo-PathyDepartment of Social and Preventive Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.
M DahluiDepartment of Social and Preventive Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.
M H SeeDepartment of Surgery, University Malaya Medical Centre University of Malaya Kuala Lumpur Malaysia.ORCID 0000-0002-7197-5759
C H YipDepartment of Surgery, University Malaya Medical Centre University of Malaya Kuala Lumpur Malaysia.
N A TaibDepartment of Surgery, University Malaya Medical Centre University of Malaya Kuala Lumpur Malaysia.
N Bhoo-PathyDepartment of Social and Preventive Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mastectomy rates among women with early breast cancer in Asia have traditionally been high. This study assessed trends in the surgical management of young women with early-stage breast cancer in Asian settings. Survival in women treated with breast-conserving surgery (BCS; lumpectomy with adjuvant radiotherapy) and those undergoing mastectomy was compared. Methods: Young women (aged less than 50 years) newly diagnosed with stage I or II (T1-2 N0-1 M0) breast cancer in four hospitals in Malaysia, Singapore and Hong Kong in 1990-2012 were included. Overall survival (OS) was compared for patients treated by BCS and those who had a mastectomy. Propensity score analysis was used to account for differences in demographic, tumour and treatment characteristics between the groups. Results: Some 63·5 per cent of 3536 women underwent mastectomy. Over a 15-year period, only a modest increase in rates of BCS was observed. Although BCS was significantly associated with favourable prognostic features, OS was not significantly different for BCS and mastectomy; the 5-year OS rate was 94·9 (95 per cent c.i. 93·5 to 96·3) and 92·9 (91·7 to 94·1) per cent respectively. Inferences remained unchanged following propensity score analysis (hazard ratio for BCS Conclusion: The prevalence of young women with breast cancer treated by mastectomy remains high in Asian countries. Patients treated with BCS appear to survive as well as those undergoing mastectomy.

Indexed as

AdultAsiaBreast NeoplasmsFemaleHumansKaplan-Meier EstimateMastectomyMastectomy, SegmentalMiddle AgedNeoplasm StagingPrognosisPropensity ScoreRadiotherapy, AdjuvantRegistries

Identifiers

PMID30734015
PMCPMC6354186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.