Evidence map›Paper›PMID 30733723›Full record

ReviewFrontiers in immunology2018

The Treatment of Giant Cell Arteritis in Different Clinical Settings.

Alexander Pfeil, Peter Oelzner, Peter Hellmann

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of temporal artery resection in Horton's arteritis (Review).Experimental and therapeutic medicine · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexander PfeilDepartment of Internal Medicine III, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Peter OelznerDepartment of Internal Medicine III, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Peter HellmannChugai Pharma Europe Ltd., Frankfurt am Main, Germany.
Friedrich Schiller University Jena · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper aims to raise awareness of the different disease courses, comorbidities, and therapy situations in patients with giant cell arteritis (GCA), which require a differentiated approach and often a deviation from current treatment guidelines. With the approval of tocilizumab (TOC), which specifically binds to both soluble and membrane-bound IL-6 receptor and inhibits IL-6 receptor-mediated signaling, the spectrum of available effective treatment options has been significantly broadened. TOC yields an extensive range of possible applications that go beyond a glucocorticoid-saving effect. In this context, the treatment of GCA is dependent on the disease course as well as the associated comorbidities. The different stages of GCA in association to co-morbidities require a detailed treatment strategy.

Indexed as

Antibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsComorbidityDrug ResistanceGiant Cell ArteritisGlucocorticoidsHumansRandomized Controlled Trials as TopicReceptors, Interleukin-6RecurrenceTreatment OutcomeAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsGlucocorticoidsReceptors, Interleukin-6tocilizumabclinical settingscomorbiditygiant cell arteritisglucocorticoidsrelapsetocilizumab

Identifiers

PMID30733723
PMCPMC6353794
OpenAlexW2914113570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.