Evidence map›Paper›PMID 30733719›Full record

ArticleFrontiers in immunology2019

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine.

Pranav Murthy, Aatur D Singhi, Mark A Ross, Patricia Loughran, Pedram Paragomi, Georgios I Papachristou, David C Whitcomb, Amer H Zureikat, Michael T Lotze, Herbert J Zeh Iii and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  7. Review
  8. Review
  9. Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Pranav MurthyDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, United States.
Mark A RossCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, United States.
Patricia LoughranCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, United States.
Pedram ParagomiDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Georgios I PapachristouDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
David C WhitcombDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Amer H ZureikatDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Michael T LotzeDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Herbert J Zeh IiiDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Brian A BooneDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
University of Pittsburgh · USThe University of Texas Southwestern Medical Center · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries · 2012 to 2026
$81.0M
(PQ5) Mitochondria are endocellular symbionts that serve as targets for immune recognitionR01CA206012 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FACCIABENE, ANDREA · 2016 to 2020
$2.0M
Pancreatic Ductal Adenocarcinoma is a disease of constitutive autophagyR01CA181450 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOTZE, MICHAEL T, ZEH, HERBERT J · 2014 to 2018
$1.6M
Request for a Nikon A1 confocal microscopeS10OD019973 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2015 to 2015
$358k
NCI NIH HHS R01 CA181450NCI NIH HHS R01 CA206012NIGMS NIH HHS U54 GM104942NIH HHS S10 OD019973
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Neutrophil InfiltrationAcute DiseaseAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersChloroquineDisease Models, AnimalExtracellular TrapsFemaleHumansInflammation MediatorsMiceMice, KnockoutNeutrophilsPancreatitisSeverity of Illness IndexAnti-Inflammatory Agents, Non-SteroidalBiomarkersChloroquineInflammation Mediatorsautophagychloroquinecitrullinated histoneneutrophil extracellular trapspancreatitissystemic inflammatory response

Identifiers

PMID30733719
PMCPMC6353831
OpenAlexW2913152905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.