Evidence map›Paper›PMID 30733585›Full record

ArticleScientific reports2019

Objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images.

Bino Varghese, Frank Chen, Darryl Hwang, Suzanne L Palmer, Andre Luis De Castro Abreu, Osamu Ukimura, Monish Aron, Manju Aron, Inderbir Gill, Vinay Duddalwar and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05911412 (Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders and Novel Treatment Strategies), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05911412 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders and Novel Treatment Strategies: Effect of Mindfulness-based Cognitive Therapy Using Neuroscience on the Brain

TypeinterventionalSponsorCHA UniversityRan2023 to 2025Enrolled64ConditionsAnxiety DepressionArmsMindfulness-based cognitive therapy using neuroscience (NMBCT)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Radiomics and Back Pain.Global spine journal · 2026
    Review
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  8. Article
  9. Article
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  12. Article
  13. Epigenetic profiling of prostate cancer reveals potential prognostic signatures.Journal of cancer research and clinical oncology · 2024
    Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bino VargheseDepartment of Radiology, University of Southern California, Los Angeles, CA, USA. bino.varghese@med.usc.edu.ORCID 0000-0002-0508-2899
Frank ChenDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0655-1490
Darryl HwangDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Suzanne L PalmerDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Andre Luis De Castro AbreuUSC Institute of Urology, Los Angeles, CA, USA.
Osamu UkimuraUSC Institute of Urology, Los Angeles, CA, USA.
Monish AronUSC Institute of Urology, Los Angeles, CA, USA.
Manju AronDepartment of Pathology, University of Southern California, Los Angeles, CA, USA.
Inderbir GillUSC Institute of Urology, Los Angeles, CA, USA.
Vinay DuddalwarDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Gaurav PandeyDepartment of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. gaurav.pandey@mssm.edu.ORCID 0000-0003-1939-679X

Funding

Promoting Institutional Communities for Open Data ScienceU24ES026465 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2015 to 2017
$7.6M
Boosting the Translational Impact of Scientific Competitions by Ensemble LearningR01GM114434 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PANDEY, GAURAV · 2015 to 2017
$1.3M
NIEHS NIH HHS U24 ES026465NIGMS NIH HHS R01 GM114434
6 · The paper itself

Abstract

Multiparametric magnetic resonance imaging (mpMRI) has become increasingly important for the clinical assessment of prostate cancer (PCa), but its interpretation is generally variable due to its relatively subjective nature. Radiomics and classification methods have shown potential for improving the accuracy and objectivity of mpMRI-based PCa assessment. However, these studies are limited to a small number of classification methods, evaluation using the AUC score only, and a non-rigorous assessment of all possible combinations of radiomics and classification methods. This paper presents a systematic and rigorous framework comprised of classification, cross-validation and statistical analyses that was developed to identify the best performing classifier for PCa risk stratification based on mpMRI-derived radiomic features derived from a sizeable cohort. This classifier performed well in an independent validation set, including performing better than PI-RADS v2 in some aspects, indicating the value of objectively interpreting mpMRI images using radiomics and classification methods for PCa risk assessment.

Indexed as

Image Processing, Computer-AssistedMachine LearningMultiparametric Magnetic Resonance ImagingAnimalsCell Line, TumorHumansImmunohistochemistryMaleMiceProstatic NeoplasmsReproducibility of ResultsRisk Assessment

Identifiers

PMID30733585
PMCPMC6367324

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.