ArticleBritish journal of cancer2019
Effect of increased body mass index on risk of diagnosis or death from cancer.
Article in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses.International journal of epidemiology · 2020Pooled it
- The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank.Frontiers in endocrinology · 2026Article
- Review
- MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies.Nature genetics · 2024Article
- Body mass index and adipose distribution have opposing genetic impacts on human blood traits.eLife · 2022Article
- Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity.Frontiers in genetics · 2022Review
- Repurposing non-invasive prenatal testing data: Population study of single nucleotide variants associated with colorectal cancer and Lynch syndrome.Oncology letters · 2021Article
- Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study.Scientific reports · 2021Article
- Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.PLoS medicine · 2021Article
- Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundWhether body mass index (BMI) is causally associated with the risk of being diagnosed with or dying from any cancer remains unclear. Weight reduction has clinical importance for cancer control only if weight gain causes cancer development or death. We aimed to answer the question 'does genetically predicted BMI influence my risk of being diagnosed with or dying from any cancer'.
methodsWe used a Mendelian randomisation (MR) approach to estimate causal effect of BMI in 46,155 white-British participants aged between 40 and 69 years at recruitment (median age at follow-up 61 years) from the UK Biobank, who developed any type of cancer, among whom 6998 died from cancer. To derive MR instruments for BMI, we selected up to 390,628 cancer-free participants.
resultsFor each standard deviation (4.78 units) increase in genetically predicted BMI, we estimated a causal odds ratio (COR) of 1.07 (1.02-1.12) and 1.28 (1.16-1.41) for overall cancer risk and mortality, respectively. The corresponding estimates were similar for males and females, and smokers and non-smokers.
conclusionsHigher genetically predicted BMI increases the risk of being diagnosed with or dying from any cancer. These data suggest that increased overall weight may causally increase overall cancer incidence and mortality among Europeans.
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