Disease modification in OA - will we ever get there?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Effects of Interleukin-1β Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial.Annals of internal medicine · 2020
   Trial
2. Association of baseline MRI-defined structural features with knee symptom trajectories over nine years: Data from the osteoarthritis initiative (OAI).Osteoarthritis imaging · 2026
   Article
3. Hip Joint Loading During Walking Is Associated With Cartilage Defect Severity in Young Adult Football Players With Hip/Groin Pain.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
   Article
4. A preliminary bioinformatic screen to identify SRI SMC2 PSIP1 TLE4 and MSX1 as potential diagnostic and prognostic markers of osteoarthritis.Scientific reports · 2025
   Article
5. Therapeutic Controlled Release Strategies for Human Osteoarthritis.Advanced healthcare materials · 2025
   Review
6. Efficacy of Intramuscular Injection of Calcitonin on Pain Functional Status of Patients with Knee Osteoarthritis.Anesthesiology and pain medicine · 2023
   Article
7. Early-stage symptomatic osteoarthritis of the knee - time for action.Nature reviews. Rheumatology · 2021
   Review
8. Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats.International journal of molecular sciences · 2021
   Article
9. Pain Trajectories in Knee Osteoarthritis-A Systematic Review and Best Evidence Synthesis on Pain Predictors.Journal of clinical medicine · 2020
   Review
10. Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International.Osteoarthritis and cartilage open · 2020
    Review

Corrections and comments

• Comment on
  Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs.2019

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as