Evidence map›Paper›PMID 30733529›Full record

ArticleScientific reports2019

Computational and spectroscopic analysis of interaction between food colorant citrus red 2 and human serum albumin.

Di Wu, Jinqiu Wang, Dayu Liu, Yin Zhang, Xia Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Di WuKey Laboratory of Meat Processing of Sichuan, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, 610106, China. diwulab@163.com.
Jinqiu WangKey Laboratory of Meat Processing of Sichuan, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, 610106, China.
Dayu LiuKey Laboratory of Meat Processing of Sichuan, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, 610106, China.
Yin ZhangKey Laboratory of Meat Processing of Sichuan, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, 610106, China.
Xia HuKey Laboratory of Meat Processing of Sichuan, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, 610106, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main aim of this work was to gain insight into the binding properties between a food colorant, citrus red 2 (CR), and human serum albumin (HSA), which is the predominant protein in blood plasma. Here, computer simulations and multiple spectroscopies were applied to predict and characterize the interaction between CR and HSA. Docking and molecular dynamics presented a stable binding configuration with low fluctuations. Fluorescence spectroscopy and lifetime results suggested that the CR-HSA combination undergoes static quenching mechanism with binding constant of 10

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationAzo CompoundsFood Coloring AgentsHumansProtein BindingProtein ConformationSerum Albumin, HumanSpectrum AnalysisAzo Compoundscitrus red No. 2Food Coloring AgentsSerum Albumin, Human

Identifiers

PMID30733529
PMCPMC6367341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.