ArticleScientific reports2019
Epigenetic mechanisms mediate the experimental evolution of resistance against parasitic fungi in the greater wax moth Galleria mellonella.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genomic responses to increased temperature and pollinator selection in Brassica rapa L.The New phytologist · 2026Article
- Review
- Chemosensory protein 16 has an immune function and participates in host-pathogen interaction inVirulence · 2025Article
- Host plant flooding stress in soybeans differentially impacts avirulent and virulent soybean aphid (Aphis glycines) biotypes.Scientific reports · 2025Article
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Epigenetic remodeling in insect immune memory.Frontiers in immunology · 2024Review
- Pest status, molecular evolution, and epigenetic factors derived from the genome assembly of Frankliniella fusca, a thysanopteran phytovirus vector.BMC genomics · 2023Article
- The SWC4 subunit of the SWR1 chromatin remodeling complex is involved in varying virulence ofVirulence · 2022Article
- Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species.iScience · 2022Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Review
- Insecticide exposure affects intergenerational patterns of DNA methylation in the Colorado potato beetle,Evolutionary applications · 2021Article
- The greater wax moth Galleria mellonella: biology and use in immune studies.Pathogens and disease · 2020Review
- Effect of Juvenile Hormone on Resistance against Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2020Article
- Reprograming of epigenetic mechanisms controlling host insect immunity and development in response to egg-laying by a parasitoid wasp.Proceedings. Biological sciences · 2020Article
- MicroRNAs regulate innate immunity against uropathogenic and commensal-like Escherichia coli infections in the surrogate insect model Galleria mellonella.Scientific reports · 2020Article
- Resistance is not the end: lessons from pest management.Cancer control : journal of the Moffitt Cancer CenterArticle
- Galleria mellonella as a Simple Yet Reliable In Vivo Model for Nanotoxicology: Techniques and Applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recent concepts in evolutionary biology suggest that epigenetic mechanisms can translate environmental selection pressures into heritable changes in phenotype. To determine whether experimental selection for a complex trait in insects involves epigenetic modifications, we carried out a generation-spanning experiment using larvae of the greater wax moth Galleria mellonella as a model host to investigate the role of epigenetics in the heritability of resistance against the parasitic fungus Metarhizium robertsii. We investigated differences in DNA methylation, histone acetylation and microRNA (miRNA) expression between an experimentally resistant population and an unselected, susceptible line, revealing that the survival of G. mellonella larvae infected with M. robertsii correlates with tissue-specific changes in DNA methylation and histone modification and the modulation of genes encoding the corresponding enzymes. We also identified miRNAs differentially expressed between resistant and susceptible larvae and showed that these regulatory molecules target genes encoding proteinases and proteinase inhibitors, as well as genes related to cuticle composition, innate immunity and metabolism. These results support our hypothesis that epigenetic mechanisms facilitate, at least in part, the heritable manifestation of parasite resistance in insects. The reciprocal adaptations underlying host-parasite coevolution therefore extend beyond the genetic level to encompass epigenetic modifications.
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