ArticleScience (New York, N.Y.)2019
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Congenital abnormalities associated with Zika virus infection-Dengue as potential co-factor? A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- The frequency and clinical presentation of Zika virus coinfections: a systematic review.BMJ global health · 2020Pooled it
- Fine-scale heterogeneity inProceedings of the National Academy of Sciences of the United States of America · 2020Trial
- A novel method for depletion of dengue virus non-structural protein 1 antibodies to determine serotype exposure history.mSphere · 2026Article
- Identification of multiple arbovirus infections/exposure in Northeastern Brazil using a multiplex microsphere immunoassay.Journal of clinical microbiology · 2026Article
- Dissecting Age-Stratified Immunity to Different Dengue Virus Serotypes and Zika Viruses Among Children in a Highly Endemic Region in Sri Lanka.Open forum infectious diseases · 2026Article
- Increased CSF volume, altered brain development and emotional reactivity after postnatal Zika virus infection in infant rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- A systematic review and meta-analysis of Zika virus epidemiology.Nature health · 2026Article
- Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection.Open forum infectious diseases · 2025Article
- Preexisting yellow fever virus and West Nile virus immunity and pregnancy outcomes in a Nigerian cohort with endemic orthoflavivirus exposure.Emerging microbes & infections · 2025Article
- Review
- Pre-existing YFV-17D immunity mediates T cell cross-protection against dengue virus serotype 2 infection in mice.Communications biology · 2025Article
- Article
- Review
- Human T Cell Responses to Flavivirus Vaccines.European journal of immunology · 2025Review
- Estimating transmissibility of Zika virus in Colombia in the presence of surveillance bias.Nature communications · 2025Article
- Seroprevalence and Placental Transfer of Zika and Dengue Virus Antibodies in Postpartum Women in Southeast Brazil.Journal of medical virology · 2025Article
- Proceedings of the second annual dengue endgame summit: A call to action.PLoS neglected tropical diseases · 2025Article
- A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure.PLoS neglected tropical diseases · 2025Article
- Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions.Emerging microbes & infections · 2024Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors.
Isabel Rodriguez-BarraquerDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-6784-1021
Federico CostaInstituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Eduardo J M NascimentoDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Nivison NeryInstituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Priscila M S CastanhaInstituto Aggeu Magalhães, Fundação Oswaldo Cruz/MS, Recife, Pernambuco, Brazil.ORCID 0000-0002-1220-5308
Gielson Almeida SacramentoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0003-2771-7282
Jaqueline CruzInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0003-4128-1008
Mayara CarvalhoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Daiana De OliveraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0003-0581-3433
José E HaganInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0002-1837-6319
Haritha AdhikarlaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0002-4217-2180
Elsio A WunderInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.ORCID 0000-0002-5239-8511
Danilo F CoêlhoInstituto Aggeu Magalhães, Fundação Oswaldo Cruz/MS, Recife, Pernambuco, Brazil.ORCID 0000-0002-1111-0825
Sasha R AzarInstitute for Translational Science, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-9182-216X
Shannan L RossiDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-2450-2374
Nikos VasilakisDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Scott C WeaverDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Guilherme S RibeiroInstituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.ORCID 0000-0002-6798-2059
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0002-7238-4037
Maurício L NogueiraFaculdade de Medicina de São Jose do Rio Preto, São Jose do Rio Preto, São Paulo, Brazil.ORCID 0000-0003-1102-2419
Mitermayer G ReisInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Ernesto T A MarquesDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3826-9358
Derek A T CummingsDepartment of Biology, University of Florida, Gainesville, FL, USA. albert.ko@yale.edu datc@ufl.edu.ORCID 0000-0002-9437-1907
Albert I KoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil. albert.ko@yale.edu datc@ufl.edu.
Funding
Vaccines and Diagnostics TrialsU54AI065359 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARBOUR, ALAN G. · 2005 to 2013
$88.8MProject 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2015 to 2021
$46.6MT Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Eva Harris · 2015 to 2026
$34.1MTraining, Outreach & Diversity ComponentU54GM088491 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKOSKI, JOAN M · 2009 to 2018
$16.7MResearch Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5MWorld Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5MDengue Epitope Vaccine,Tetravalent &MHCII-TargetedU19AI056541 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AUGUST, J. THOMAS · 2003 to 2007
$6.8MNaturally-Acquired and Vaccine-Mediated Immunity to LeptospirosisR01AI121207 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG, REIS, MITERMAYER GALVAO DOS · 2016 to 2020
$6.4MGlobal Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2MDisease Determinants of Urban LeptospirosisU01AI088752 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2010 to 2014
$3.6MLINKING ANTIGENIC & GENETIC VARIATION OF DENGUE TO INDIVIDUAL AND POPULATION RISKR01AI114703 · NIAID · UNIVERSITY OF FLORIDA · PI CUMMINGS, DEREK A · 2015 to 2019
$3.6MNatural History of Urban LeptospirosisR01AI052473 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2003 to 2013
$2.8MFIC NIH HHS D43 TW010540FIC NIH HHS R01 TW009504FIC NIH HHS R25 TW009338NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI052473NIAID NIH HHS R01 AI099631NIAID NIH HHS R01 AI114703NIAID NIH HHS R01 AI121207NIAID NIH HHS R24 AI120942NIAID NIH HHS U01 AI088752NIAID NIH HHS U01 AI115577NIAID NIH HHS U19 AI056541NIAID NIH HHS U19 AI118610NIAID NIH HHS U54 AI065359NIGMS NIH HHS U54 GM088491NINDS NIH HHS R01 NS064905Wellcome Trust
Abstract
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
Indexed as
Cross ReactionsAdolescentAdultAntibodies, ViralBasic Reproduction NumberBrazilChildDengueDisease OutbreaksFemaleHumansImmunoglobulin GMaleProspective StudiesSeroepidemiologic StudiesUrban PopulationAntibodies, ViralImmunoglobulin GNS1 protein, dengue-1 virusNS1 protein, zika virusViral Nonstructural Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.