Evidence map›Paper›PMID 30733291›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Grammar of protein domain architectures.

Lijia Yu, Deepak Kumar Tanwar, Emanuel Diego S Penha, Yuri I Wolf, Eugene V Koonin, Malay Kumar Basu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Protein Structure Prediction Methods.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Clustering protein functional families at large scale with hierarchical approaches.Protein science : a publication of the Protein Society · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijia YuDepartment of Pathology, University of Alabama, Birmingham, AL 35249.ORCID 0000-0001-6735-9569
Deepak Kumar TanwarDepartment of Pathology, University of Alabama, Birmingham, AL 35249.ORCID 0000-0001-8036-1989
Emanuel Diego S PenhaDepartment of Pathology, University of Alabama, Birmingham, AL 35249.
Yuri I WolfNational Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894.
Eugene V KooninNational Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894 malay@uab.edu koonin@ncbi.nlm.nih.gov.ORCID 0000-0003-3943-8299
Malay Kumar BasuDepartment of Pathology, University of Alabama, Birmingham, AL 35249; malay@uab.edu koonin@ncbi.nlm.nih.gov.ORCID 0000-0002-8008-4042

Funding

Finding Protein Sequence Motifs--Methods And ApplicationsZIALM000061 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 2009 to 2025
$10.6M
6 · The paper itself

Abstract

From an abstract, informational perspective, protein domains appear analogous to words in natural languages in which the rules of word association are dictated by linguistic rules, or grammar. Such rules exist for protein domains as well, because only a small fraction of all possible domain combinations is viable in evolution. We employ a popular linguistic technique,

Indexed as

Evolution, MolecularProtein Structure, TertiaryArchaeaFemaleHumansLinguisticsMalePhylogenyProtein DomainsProteomeProteomebigramdomain architecturelanguagen-gramprotein domain

Identifiers

PMID30733291
PMCPMC6397568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.