ArticleHaematologica2019
Anti-apoptotic
Open access · goldAbstract read
In one paragraph
Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Isolation of Human Umbilical Cord Blood Hematopoietic Stem Cells and Directed Differentiation Into Megakaryocytes.Bio-protocol · 2026Article
- Functional classification of platelet gene variants using CRISPR HDR in CD34American journal of human genetics · 2025Article
- Platelet-derived thrombospondin 1 promotes immune cell liver infiltration and exacerbates diet-induced steatohepatitis.JHEP reports : innovation in hepatology · 2024Article
- Immune attack on megakaryocytes in immune thrombocytopenia.Research and practice in thrombosis and haemostasis · 2024Article
- Oxidative Stress Mediates Epigenetic Modifications and the Expression of miRNAs and Genes Related to Apoptosis in Diabetic Retinopathy Patients.Journal of clinical medicine · 2023Article
- Enkurin: a novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.Blood advances · 2023Article
- MALAT1 promotes platelet activity and thrombus formation through PI3k/Akt/GSK-3β signalling pathway.Stroke and vascular neurology · 2023Article
- Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.bioRxiv : the preprint server for biology · 2023Article
- A New Role of NAP1L1 in Megakaryocytes and Human Platelets.International journal of molecular sciences · 2022Article
- Toward in Vitro Production of Platelet from Induced Pluripotent Stem Cells.Stem cell reviews and reports · 2022Review
- Interferon α-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation.Haematologica · 2022Article
- Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis.Frontiers in immunology · 2022Review
- Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia.Frontiers in immunology · 2022Article
- MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.Cellular oncology (Dordrecht, Netherlands) · 2021Article
- CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.Blood advances · 2021Article
- Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and plateletsHaematologica · 2021Review
- Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with platelets?Journal of thrombosis and haemostasis : JTH · 2021Review
- miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin.Blood · 2020Article
- BCL-w: apoptotic and non-apoptotic role in health and disease.Cell death & disease · 2020Review
- Role of Platelet Mitochondria: Life in a Nucleus-Free Zone.Frontiers in cardiovascular medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Seema BhatlekarProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Indranil BasakProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Leonard C EdelsteinCardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA.
Robert A CampbellProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Cory R LindseyCardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA.
Joseph E ItalianoBrigham and Women's Hospital, Harvard University, Boston, MA.
Andrew S WeyrichProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Jesse W RowleyProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Matthew T RondinaProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Martha Sola-VisnerBoston Children's Hospital, Harvard University, Boston, MA.
Paul F BrayProgram in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT paul.bray@hsc.utah.edu.
University of Utah · USThomas Jefferson University · USBrigham and Women's Hospital · USGeorge E. Wahlen Department of VA Medical Center · USHarvard University · US
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6MCytoskeletal Mechanisms of Platelet FormationR01HL068130 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ITALIANO, JOSEPH E · 2001 to 2021
$8.1MVariation in platelet function: the genetics of platelet gene expressionR01HL102482 · NHLBI · UNIVERSITY OF UTAH · PI BRAY, PAUL F. · 2010 to 2018
$4.6MMitochondrial fusion protein MFN2 prevents platelet death and dysfunctionR01HL144957 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JESSE ROWLEY · 2019 to 2026
$3.2MIn vivo studies of megakaryocyte microRNAs regulating platelet number and integrin activationR01HL141424 · NHLBI · UNIVERSITY OF UTAH · PI BRAY, PAUL F. · 2018 to 2021
$2.5MMicroRNA function in human megakaryocytesR01HL116713 · NHLBI · UNIVERSITY OF UTAH · PI BRAY, PAUL F. · 2014 to 2017
$1.7MInterferon-Induced Transmembrane Protein 3 (IFITM3) Regulates Thrombosis During Inflammation in AgingK01AG059892 · NIA · UNIVERSITY OF UTAH · PI CAMPBELL, ROBERT A · 2019 to 2022
$400kNCI NIH HHS P30 CA042014NHLBI NIH HHS R01 HL068130NHLBI NIH HHS R01 HL102482NHLBI NIH HHS R01 HL116713NHLBI NIH HHS R01 HL141424NHLBI NIH HHS R01 HL144957NIA NIH HHS K01 AG059892
Abstract
Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied
Indexed as
Fetal BloodMegakaryocytesAntigens, DifferentiationApoptosis Regulatory ProteinsCells, CulturedFlow CytometryGene Expression RegulationHumansAntigens, DifferentiationApoptosis Regulatory ProteinsBCL2L2 protein, human
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What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.