ArticleAJNR. American journal of neuroradiology2019
Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-1β -511C>T (Part I).Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II).Acta bio-medica : Atenei Parmensis · 2022Pooled it
- The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review.Neurosurgical review · 2022Pooled it
- Associations between middle cerebral artery tortuosity, aneurysm wall enhancement, and hemodynamics assessed by four-dimensional-flow and high-resolution magnetic resonance imaging.Neuroradiology · 2026Article
- Novel Morphological Classification of Intracranial Aneurysm Wall Irregularity Associates Specific Features with Increased Size and Rupture Risk: A Retrospective Single-Center Cross-Sectional Study.Neurology international · 2026Article
- Investigation of Contrast Retention in PCOM Aneurysms as a Possible Marker for Instability and Rupture.International journal for numerical methods in biomedical engineering · 2026Article
- Collagen Imaging in Human Intracranial Aneurysms - a Translational Proof-of-Concept Study.Translational stroke research · 2026Article
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences.Stroke (Hoboken, N.J.) · 2025Article
- Flow patterns inside the cerebral aneurysms affect aneurysm wall thickness.Neurosurgical review · 2025Observational
- Haemodynamic characteristics of thin-walled regions in intracranial aneurysms: intraoperative imaging and CFD analysis.Acta neurochirurgica · 2025Article
- Comprehensive morphomechanical and wall enhancement analysis of intracranial aneurysms.European radiology · 2025Article
- Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques.Translational stroke research · 2025Review
- Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation.Nature cardiovascular research · 2025Observational
- Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall.International journal for numerical methods in biomedical engineering · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Characterization of Maximum Wall Shear Stress Points in Unruptured Cerebral Aneurysms Using Four-dimensional Flow Magnetic Resonance Imaging.Clinical neuroradiology · 2024Article
- Clinical and Hemodynamic Features of Aneurysm Rupture in Coil Embolization of Intracranial Aneurysms.Diagnostics (Basel, Switzerland) · 2024Article
- Endovascular Treatment of Intracranial Aneurysm: The Importance of the Rheological Model in Blood Flow Simulations.Bioengineering (Basel, Switzerland) · 2024Article
- Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
background and purposeAneurysm hemodynamics has been associated with wall histology and inflammation. We investigated associations between local hemodynamics and focal wall changes visible intraoperatively. MATERIALS AND
methodsComputational fluid dynamics models were constructed from 3D images of 65 aneurysms treated surgically. Aneurysm regions with different visual appearances were identified in intraoperative videos: 1) "atherosclerotic" (yellow), 2) "hyperplastic" (white), 3) "thin" (red), 4) rupture site, and 5) "normal" (similar to parent artery), They were marked on 3D reconstructions. Regional hemodynamics was characterized by the following: wall shear stress, oscillatory shear index, relative residence time, wall shear stress gradient and divergence, gradient oscillatory number, and dynamic pressure; these were compared using the Mann-Whitney test.
resultsHyperplastic regions had lower average wall shear stress (
conclusionsLocal hemodynamics is associated with visible focal wall changes. Slow swirling flow with low and oscillatory wall shear stress was associated with atherosclerotic and hyperplastic changes. High flow conditions prevalent in regions near the flow impingement site characterized by higher and less oscillatory wall shear stress were associated with local "thinning" of the wall.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.