Evidence map›Paper›PMID 30733243›Full record

ArticleThe EMBO journal2019

Endophilin-A regulates presynaptic Ca

Jana Kroll, Lina M Jaime Tobón, Christian Vogl, Jakob Neef, Ilona Kondratiuk, Melanie König, Nicola Strenzke, Carolin Wichmann, Ira Milosevic, Tobias Moser

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. DMXL2 Is Required for Endocytosis and Recycling of Synaptic Vesicles in Auditory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Probing the role of the CFrontiers in molecular neuroscience · 2023
    Article
  14. Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Organization of Presynaptic Autophagy-Related Processes.Frontiers in synaptic neuroscience · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jana KrollSynaptic Vesicle Dynamics Group, European Neuroscience Institute (ENI), University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-4243-4088
Lina M Jaime TobónCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.ORCID 0000-0002-6752-7750
Christian VoglCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.ORCID 0000-0003-4432-2733
Jakob NeefCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.
Ilona KondratiukSynaptic Vesicle Dynamics Group, European Neuroscience Institute (ENI), University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-7740-8923
Melanie KönigSynaptic Vesicle Dynamics Group, European Neuroscience Institute (ENI), University Medical Center Göttingen, Göttingen, Germany.
Nicola StrenzkeCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.ORCID 0000-0003-1673-1046
Carolin WichmannMolecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany carolin.wichmann@med.uni-goettingen.de i.milosevic@eni-g.de tmoser@gwdg.de.ORCID 0000-0001-8868-8716
Ira MilosevicSynaptic Vesicle Dynamics Group, European Neuroscience Institute (ENI), University Medical Center Göttingen, Göttingen, Germany carolin.wichmann@med.uni-goettingen.de i.milosevic@eni-g.de tmoser@gwdg.de.ORCID 0000-0001-6440-3763
Tobias MoserCollaborative Research Center 889, University of Göttingen, Göttingen, Germany carolin.wichmann@med.uni-goettingen.de i.milosevic@eni-g.de tmoser@gwdg.de.ORCID 0000-0001-7145-0533
Universitätsmedizin Göttingen · DEMax Planck Institute of Experimental Medicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribbon synapses of cochlear inner hair cells (IHCs) operate with high rates of neurotransmission; yet, the molecular regulation of synaptic vesicle (SV) recycling at these synapses remains poorly understood. Here, we studied the role of endophilins-A1-3, endocytic adaptors with curvature-sensing and curvature-generating properties, in mouse IHCs. Single-cell RT-PCR indicated the expression of endophilins-A1-3 in IHCs, and immunoblotting confirmed the presence of endophilin-A1 and endophilin-A2 in the cochlea. Patch-clamp recordings from endophilin-A-deficient IHCs revealed a reduction of Ca

Indexed as

AcyltransferasesAnimalsCalciumCochleaEndocytosisExocytosisFemaleHair Cells, AuditoryMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutPresynaptic TerminalsSynapsesSynaptic Transmission2-acylglycerophosphate acyltransferaseAcyltransferasesCalciumMembrane Proteinsotoferlin protein, mouseelectron microscopyendocytosismembrane capacitanceribbon synapsesuper‐resolution microscopy

Identifiers

PMID30733243
PMCPMC6396150
OpenAlexW2912497031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.