Evidence map›Paper›PMID 30733237›Full record

ArticleDisease models & mechanisms2019

Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease.

Amanda Havighorst, Youwen Zhang, Elena Farmaki, Vimala Kaza, Ioulia Chatzistamou, Hippokratis Kiaris

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amanda HavighorstDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208-3402, USA.
Youwen ZhangDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208-3402, USA.
Elena FarmakiDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208-3402, USA.
Vimala KazaPeromyscus Genetic Stock Center, University of South Carolina, Columbia, SC 29208-3402, USA.
Ioulia ChatzistamouDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208-3402, USA.
Hippokratis KiarisDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208-3402, USA hk@sc.edu.ORCID 0000-0002-8999-8289
University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress has been causatively linked to the onset of various pathologies. However, whether and how inherent variations in the resulting unfolded protein response (UPR) affect predisposition to ER-stress-associated metabolic conditions remains to be established. By using genetically diverse deer mice (

Indexed as

Unfolded Protein ResponseAltitudeAnimalsAnimals, Outbred StrainsCells, CulturedDiet, High-FatDisease SusceptibilityFatty LiverFemaleFibroblastsGene Expression RegulationLipidsMaleMetabolic DiseasesPeromyscusTranscription FactorsLipidsTranscription FactorsER stressExpression profileLipidemiaPrediction

Identifiers

PMID30733237
PMCPMC6398494
OpenAlexW2911705400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.