Evidence map›Paper›PMID 30733232›Full record

ArticleThe Journal of general physiology2019

Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis.

Wentao Mi, Fenfen Wu, Marbella Quinonez, Marino DiFranco, Stephen C Cannon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier KProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Periodic paralysis.Handbook of clinical neurology · 2024
    Review
  4. Review
  5. Review
  6. Treatment Updates for Neuromuscular Channelopathies.Current treatment options in neurology · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wentao MiDepartment of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX.
Fenfen WuDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Marbella QuinonezDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0002-0684-9705
Marino DiFrancoDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0002-9315-9429
Stephen C CannonDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA sccannon@mednet.ucla.edu.ORCID 0000-0001-8428-3690
University of California, Los Angeles · USSouthwestern Medical Center · US

Funding

Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic ParalysisR01AR063182 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI STEPHEN C. CANNON · 2012 to 2026
$6.0M
Molecular Physiology of Myotonia and Periodic ParalysisR37AR042703 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CANNON, STEPHEN C. · 2008 to 2018
$4.2M
MOLECULAR PHYSIOLOGY OF NEUROMUSCULAR DISEASESR01AR042703 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CANNON, STEPHEN C. · 1994 to 2007
$2.4M
Optogenetic control of skeletal muscle excitabilityR21AR067422 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI FRANCO, MARINO, VERGARA, JULIO L · 2014 to 2015
$373k
Opto-Electrophysiological Method to Study Human Skeletal Muscle ChannelopathiesR21AR080282 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI FRANCO, MARINO, SHIEH, PERRY · 2022 to 2023
$360k
NIAMS NIH HHS R01 AR042703NIAMS NIH HHS R01 AR063182NIAMS NIH HHS R21 AR067422NIAMS NIH HHS R21 AR080282NIAMS NIH HHS R37 AR042703
6 · The paper itself

Abstract

Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability. Episodes are often triggered by environmental stresses, such as changes in extracellular K

Indexed as

Muscle ContractionAcidosisAnimalsGene Knock-In TechniquesHydrogen-Ion ConcentrationHypokalemic Periodic ParalysisMiceMuscle, SkeletalMutationPotassiumPotassium

Identifiers

PMID30733232
PMCPMC6445579
OpenAlexW2940825331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.