Evidence map›Paper›PMID 30733167›Full record

Trial reportSchizophrenia research2019

Development and testing of a web-based battery to remotely assess cognitive health in individuals with schizophrenia.

Bruno Biagianti, Melissa Fisher, Benjamin Brandrett, Danielle Schlosser, Rachel Loewy, Mor Nahum, Sophia Vinogradov

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Bruno BiagiantiPosit Science, Inc., United States of America. Electronic address: bruno.biagianti@positscience.com.
Melissa FisherDepartment of Psychiatry, University of Minnesota, United States of America.
Benjamin BrandrettDepartment of Psychiatry, University of California, San Francisco, United States of America.
Danielle SchlosserDepartment of Psychiatry, University of California, San Francisco, United States of America; Verily Life Sciences, United States of America.
Rachel LoewyDepartment of Psychiatry, University of California, San Francisco, United States of America.
Mor NahumSchool of Occupational Therapy, Hebrew University of Jerusalem, Israel.
Sophia VinogradovDepartment of Psychiatry, University of Minnesota, United States of America.
University of California, San Francisco · USUniversity of Minnesota · USHebrew University of Jerusalem · ILPosit Science (United States) · US

Funding

Community-Based Cognitive Training in Early SchizophreniaR01MH102063 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOEWY, RACHEL L., VINOGRADOV, SOPHIA · 2013 to 2017
$3.4M
Optimizing Cognitive Remediation Outcomes in SchizophreniaR01MH082818 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2009 to 2013
$2.9M
Computerized Social Cognition training for SchizophreniaR44MH091793 · NIMH · POSIT SCIENCE CORPORATION · PI LEE, HYUN KYU · 2014 to 2016
$1.5M
PRIME to Action: Enhancing Motivation in Recent Onset SchizophreniaK23MH097795 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHLOSSER, DANIELLE A. · 2013 to 2016
$704k
Creating Live Interactions to Mitigate Barriers (CLIMB): A Mobile Intervention to Improve Social Functioning in People With SchizophreniaR43MH114765 · NIMH · POSIT SCIENCE CORPORATION · PI BIAGIANTI, BRUNO · 2018 to 2018
$246k
NIMH NIH HHS K23 MH097795NIMH NIH HHS R01 MH082818NIMH NIH HHS R01 MH102063NIMH NIH HHS R43 MH114765NIMH NIH HHS R44 MH091793
6 · The paper itself

Abstract

Cognitive impairment in schizophrenia is often severe, enduring, and contributes significantly to chronic disability. A standardized platform for identifying cognitive impairments and measuring treatment effects in cognition is a critical aspect of comprehensive evaluation and treatment for individuals with schizophrenia. In this project, we developed and tested a suite of ten web-based, neuroscience-informed cognitive assessments that are designed to enable the interpretation of specific deficits that could signal that an individual is experiencing cognitive difficulties. The assessment suite assays speed of processing, sustained attention, executive functioning, learning and socio-affective processing in the auditory and visual modalities. We have obtained data from 283 healthy individuals who were recruited online and 104 individuals with schizophrenia who also completed formal neuropsychological testing. Our data show that the assessments 1) are acceptable and tolerable to users, with successful completion in an average of under 40 min; 2) reliably measure the distinct theoretical cognitive constructs they were designed to assess; 3) can discriminate schizophrenia patients from healthy controls with a fair degree of accuracy (AUROC > 0.70); and 4) have promising construct, convergent, and external validity. Further optimization and validation work is in progress to finalize the evaluation process prior to promoting the dissemination of these assessments in real-world settings.

Indexed as

CognitionDiagnosis, Computer-AssistedMental Status and Dementia TestsSchizophrenic PsychologyTelemedicineAdultAttentionAuditory PerceptionEmotionsExecutive FunctionFemaleHumansInternetMalePatient Acceptance of Health CareReproducibility of ResultsAssessment batteryDigital healthNeurocognitionSchizophrenia

Identifiers

PMID30733167
PMCPMC6544475
OpenAlexW2913267325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.