Evidence map›Paper›PMID 30732713›Full record

ArticleJournal of the American College of Cardiology2019

Direct Current Cardioversion of Atrial Arrhythmias in Adults With Cardiac Amyloidosis.

Edward A El-Am, Angela Dispenzieri, Rowlens M Melduni, Naser M Ammash, Roger D White, David O Hodge, Peter A Noseworthy, Grace Lin, Sorin V Pislaru, Alexander C Egbe and 2 more

Abstract read
In one paragraph

Article in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 191 citations in OpenAlex.

  1. Cardiac amyloidosis: what every interventional cardiologist should know.Cardiovascular intervention and therapeutics · 2026
    Review
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  13. Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025
    Article
  14. Review
  15. Review
  16. Acute Limb Ischemia Presenting as a Clinical Conundrum: Stroke Mimic or Aortic Dissection?European journal of case reports in internal medicine · 2025
    Article
  17. Review
  18. Article
  19. [Arrhythmias and amyloidosis].Herzschrittmachertherapie & Elektrophysiologie · 2024
    Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Edward A El-AmDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: https://twitter.com/EdwardElAmm.
Angela DispenzieriDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Rowlens M MelduniDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Naser M AmmashDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Roger D WhiteDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
David O HodgeBiomedical Science and Informatics, Mayo Clinic, Jacksonville, Florida.
Peter A NoseworthyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Grace LinDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Sorin V PislaruDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Alexander C EgbeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Martha GroganDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: https://twitter.com/MarthaGrogan1.
Vuyisile T NkomoDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: nkomo.vuyisile@mayo.edu.
Mayo Clinic · USTwitter (United States) · USMayo Clinic in Florida · US

Funding

The Role of Autoimmune Mechanisms in the Pathogenesis of Atrial FibrillationK01HL135288 · NHLBI · MAYO CLINIC ROCHESTER · PI MELDUNI, ROWLENS MICHEL · 2017 to 2021
$854k
NHLBI NIH HHS K01 HL135288
6 · The paper itself

Abstract

backgroundArrhythmias, conduction abnormalities, and intracardiac thrombus are common in patients with cardiac amyloidosis (CA). Outcomes of direct-current cardioversion (DCCV) for atrial arrhythmias in patients with CA are unknown.

objectivesThis study sought to examine DCCV procedural outcomes in patients with CA.

methodsPatients with CA scheduled for DCCV for atrial arrhythmias from January 2000 through December 2012 were identified and matched 2:1 with control patients by age, sex, type of atrial arrhythmia, and date of DCCV.

resultsCA patients (n = 58, mean age 69 ± 9 years, 81% male) were included. CA patients had a significantly higher cardioversion cancellation rate (28% vs. 7%; p < 0.001) compared with control patients, mainly due to intracardiac thrombus identified on transesophageal echocardiogram (13 of 16 [81%] vs. 2 of 8 [25%]; p = 0.02); 4 of 13 of the CA patients (31%) with intracardiac thrombus on transesophageal echocardiogram received adequate anticoagulation ≥3 weeks and another 2 of 13 (15%) had arrhythmia duration <48 h. DCCV success rate (90% vs. 94%; p = 0.4) was not different. Procedural complications were more frequent in CA versus control patients (6 of 42 [14%] vs. 2 of 106 [2%]; p = 0.007); complications in CA included ventricular arrhythmias in 2 and severe bradyarrhythmias requiring pacemaker implantation in 2. The only complication in the control group was self-limited bradyarrhythmias.

conclusionsPatients with CA undergoing DCCV had a significantly high cancellation rate mainly due to a high incidence of intracardiac thrombus even among patients who received adequate anticoagulation. Although the success rate of restoring sinus rhythm was high, tachyarrhythmias and bradyarrhythmias complicating DCCV were significantly more frequent in CA patients compared with control patients.

Indexed as

AmyloidosisAtrial FibrillationElectric CountershockHeart DiseasesThrombosisAgedContraindications, ProcedureEchocardiography, TransesophagealFemaleHumansMaleMiddle AgedMinnesotaOutcome Assessment, Health CareRetrospective StudiesRisk Adjustmentatrial arrhythmiaatrial fibrillationcardiac amyloidosiscardioversionintracardiac thrombustransesophageal echocardiogram

Identifiers

PMID30732713
PMCPMC6378685
OpenAlexW2913976779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.