ArticleDiagnostic pathology2019
Primary renal well-differentiated neuroendocrine tumors: report of six cases with an emphasis on the Ki-67 index and mitosis.
Article in Diagnostic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cage-Farming Causes Histopathological Alterations in the Renal Tissues of the Rainbow TroutInternational journal of molecular sciences · 2025Article
- Clinical and pathological analysis of primary well-differentiated neuroendocrine tumors in the kidney- a case series.BMC urology · 2025Article
- Primary Renal Neuroendocrine Tumor Presenting as Ectopic ACTH Syndrome.JCEM case reports · 2025Article
- Basic science and translational implications of current knowledge on neuroendocrine tumors.The Journal of clinical investigation · 2025Review
- Diagnosis and treatment of renal neuroendocrine tumors: a case report and literature review.Frontiers in oncology · 2025Article
- Atypical carcinoid of the primary kidney with retroperitoneal metastasis 15 years later: A case report and literature review.Urology case reports · 2025Article
- Therapeutic Response to PRRNT in a Rare Case of Metastatic Renal Neuroendocrine Carcinoma.World journal of nuclear medicine · 2024Article
- Rare renal well-differentiated neuroendocrine tumors: clinical and imaging characteristics in a series of three cases.Quantitative imaging in medicine and surgery · 2024Article
- Renal neuroendocrine tumour with preoperative diagnostic dilemma.BMJ case reports · 2023Article
- Renal neuroendocrine tumors: clinical and molecular pathology with an emphasis on frequent association with ectopic Cushing syndrome.Virchows Archiv : an international journal of pathology · 2023Article
- Primary neuroendocrine neoplasms of the kidney: a case report and literature review.The Journal of international medical research · 2023Review
- [New WHO classification 2022: urinary bladder cancer].Pathologie (Heidelberg, Germany) · 2023Article
- Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future.Endocrine pathology · 2023Review
- A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature.Cureus · 2021Article
- Primary Renal Carcinoid Tumor: Report of Two Cases.The Permanente journal · 2020Article
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Abstract
backgroundPrimary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.
methodsSix cases of primary renal WDNET were collected. After reviewing slides stained with hematoxylin and eosin, proportions of each growth pattern were determined. Synaptophysin, chromogranin, CD56, and Ki-67 immunostaining and Ki-67 morphometric analysis were performed.
resultsPatients included three female and three males, mean age was 53.3 years. The mean tumor size was 4.5 cm, three cases were greater than 5 cm. At the time of initial surgery, lymph node and/or distant metastasis was confirmed in two cases. In a third case, no metastasis was initially found, but lymph node metastasis was identified during follow-up. The remaining three cases did not exhibit metastasis. Histopathologically, the renal WDNETs were primarily composed of ribbon-like and sheet-like growth patterns. Most of the tumors were diffusely positive for neuroendocrine markers. Mitotic count was high (≥2/10HPF) in cases with lymph node or distant metastasis but was low (< 2/10HPF) in non-metastatic cases. Furthermore, the Ki-67 index was also higher (≥3%) in the cases with metastases than in cases without metastasis.
conclusionThree out of the six primary renal WDNETs demonstrated aggressive behavior and exhibited increased mitotic counts and Ki-67 indices. These results suggest that mitosis and the Ki-67 index could be used as prognostic indicators for renal WDNET.
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