ArticleBMC biology2019
Transcriptome, proteome and draft genome of Euglena gracilis.
Article in BMC biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Integrated transcriptomic and hormonomic insights into cadmium tolerance of aMicrobiology (Reading, England) · 2026Article
- Derlin-like proteins are essential for the function of Euglena gracilis chloroplasts.Plant physiology · 2026Article
- Light quality rewires module-trait networks in Euglena gracilis to drive carotenoid and paramylon accumulation.Biotechnology for biofuels and bioproducts · 2026Article
- Review
- Affordable CRISPR RNP-Based Genome Editing in Euglena gracilis.Current protocols · 2026Article
- Why Euglenozoans.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Poly(A) Profiling for Euglenozoans Using Oxford Nanopore Direct RNA Sequencing, Illustrated by the Example of Euglena gracilis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The mitochondrial proteome of diplonemids: from conventional pathways to eccentric RNA editing and transcript processing.BMC genomics · 2025Article
- Structural insights into the divergent evolution of a photosystem I supercomplex inScience advances · 2025Article
- Genetic dissection of nonconventional introns reveals codominant noncanonical splicing code inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of unique mitotic mechanisms inOpen biology · 2025Article
- Peculiar proteome of dark-cultivated Euglena gracilis.Scientific reports · 2025Article
- Comprehensive genomic and transcriptomic analysis of inositol phosphate-metabolizing enzymes in Euglena gracilis.Planta · 2025Article
- Visualisation ofLife science alliance · 2025Article
- Discovery of a parallel family of euglenatide analogs in Euglena gracilis.Natural products and bioprospecting · 2025Article
- Variable Bioproduction with Euglena gracilis: A Function of Light Flux or Carbon Source, Supplements, and Time.Advances in biochemical engineering/biotechnology · 2025Review
- Article
- Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote.BMC biology · 2024Article
- A lineage-specific protein network at the trypanosome nuclear envelope.Nucleus (Austin, Tex.) · 2024Article
- Euglena mutabilis exists in a FAB consortium with microbes that enhance cadmium tolerance.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
backgroundPhotosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gracilis has been a popular model organism and of considerable biotechnological interest, but the absence of a gene catalogue has hampered both basic research and translational efforts.
resultsWe report a detailed transcriptome and partial genome for E. gracilis Z1. The nuclear genome is estimated to be around 500 Mb in size, and the transcriptome encodes over 36,000 proteins and the genome possesses less than 1% coding sequence. Annotation of coding sequences indicates a highly sophisticated endomembrane system, RNA processing mechanisms and nuclear genome contributions from several photosynthetic lineages. Multiple gene families, including likely signal transduction components, have been massively expanded. Alterations in protein abundance are controlled post-transcriptionally between light and dark conditions, surprisingly similar to trypanosomatids.
conclusionsOur data provide evidence that a range of photosynthetic eukaryotes contributed to the Euglena nuclear genome, evidence in support of the 'shopping bag' hypothesis for plastid acquisition. We also suggest that euglenids possess unique regulatory mechanisms for achieving extreme adaptability, through mechanisms of paralog expansion and gene acquisition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.