ArticleJournal of stroke2019
Does Clot Burden Score on Baseline T2*-MRI Impact Clinical Outcome in Acute Ischemic Stroke Treated with Mechanical Thrombectomy?
Article in Journal of stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effect of Clot Burden Score on Safety and Efficacy of Intravenous Alteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Subgroup Analysis of a Randomized Phase 3 Trial.AJNR. American journal of neuroradiology · 2024Trial
- Clinical Effects of Using the Combined Technique in the First Attempt for Acute Large-vessel Occlusion, with Specific Reference to Age Differences.Neurologia medico-chirurgica · 2026Article
- Efficacy Assessment of the TIMSO Microcatheter for Endovascular Thrombectomy in the Treatment of Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2026Article
- RETRACTED: Rescue intracranial stenting in acute ischemic stroke (study).Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Vessel deviation during stent retrieval predicts successful recanalization in stent-based mechanical thrombectomy for M2 occlusion.Neuroradiology · 2025Article
- Article
- Balloon angioplasty as first-choice recanalization strategy for intracranial atherosclerosis-related emergent large vessel occlusion with small clot burden.Neuroradiology · 2024Article
- Association Between MR-Based Thrombus Imaging Characteristics and Endovascular Therapy Outcome in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Imaging features of cardioembolic stroke on 4-dimensional computed tomography angiography.Quantitative imaging in medicine and surgery · 2023Article
- Proposal of multimodal computed tomography-based scoring system in prediction of hemorrhagic transformation in acute ischemic stroke.Acta neurologica Belgica · 2023Article
- Multi-Mode Imaging Scale for Endovascular Therapy in Patients with Acute Ischemic Stroke (META).Brain sciences · 2022Article
- Factors That Influence Susceptibility Vessel Sign in Patients With Acute Stroke Referred for Mechanical Thrombectomy.Frontiers in neurology · 2022Article
- Risks of Undersizing Stent Retriever Length Relative to Thrombus Length in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2021Article
- Radiology-Pathology Correlations of Intracranial Clots: Current Theories, Clinical Applications, and Future Directions.AJNR. American journal of neuroradiology · 2021Review
- Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion.Journal of stroke · 2021Article
- Initial Clinical Experience of Repeat Thrombectomy with a Retrieval Stent (RTRS) with Continuous Proximal Flow Arrest by Balloon Guide Catheter for Acute Intracranial Carotid Occlusion.Behavioural neurology · 2021Article
- Impact of Clot Shape on Successful M1 Endovascular Reperfusion.Frontiers in neurology · 2021Article
- Clot Burden Score and Collateral Status and Their Impact on Functional Outcome in Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2021Article
- Large Artery Atherosclerotic Clots are Larger than Clots of other Stroke Etiologies and have Poorer Recanalization rates.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- Accuracy of MRI T2*-weighted sequences (GRE-EPI) compared to CTA for detection of anterior circulation large vessel thrombus.Emergency radiology · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeA long clot, defined by a low (0-6) clot burden score (CBS) assessed by T2*-MR sequence, is associated with worse clinical outcome after intravenous thrombolysis (IVT) for acute ischemic stroke than is a small clot (CBS, 7-10). The added benefit of mechanical thrombectomy (MT) might be higher in patients with long clot. The aim of this pre-specified post hoc analysis of the THRombectomie des Artères CErebrales (THRACE) trial was to assess the association between T2*-CBS, successful recanalization and clinical outcome.
methodsOf 414 patients randomized in the THRACE trial, 281 patients were included in this analysis. Associations between T2*-CBS and clinical outcome on the modified Rankin Scale (mRS) at 3 months were tested.
resultsHigh T2*-CBS, i.e., small clot, was associated with a shift toward better outcome on the mRS; proportional odds ratio (POR) per point CBS was 1.19 (95% confidence interval [CI], 1.05 to 1.34) in the whole population, 1.34 (95% CI, 1.13 to 1.59) in IVT group, and 1.04 (95% CI, 0.87 to 1.23) in IVTMT group. After adjustment for baseline prognostic variables, the effect of the full scale T2*-CBS was not statistically significant in the whole population and for the IVTMT group but remains significant for the IVT group (POR, 1.32; 95% CI, 1.11 to 1.58).
conclusions A small clot, as assessed using T2*-CBS, is associated with improved outcome and may be used as a prognostic marker. Despite the worst outcome with long clot, the relative benefit of MT over IVT seemed to increase with low T2*-CBS and longer clot.
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