Evidence map›Paper›PMID 30731481›Full record

ArticleAmerican journal of perinatology2020

Sex-Specific Genetic Susceptibility to Adverse Neurodevelopmental Outcome in Offspring of Pregnancies at Risk of Early Preterm Delivery.

Michael W Varner, Maged M Costantine, Kathleen A Jablonski, Dwight J Rouse, Brian M Mercer, Kenneth J Leveno, Uma M Reddy, Catalin Buhimschi, Ronald J Wapner, Yoram Sorokin and 9 more

Open access · greenAbstract read
In one paragraph

Article in American journal of perinatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 18 institutions in 1 country.

Michael W VarnerDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.
Maged M CostantineDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
Kathleen A JablonskiDepartment of Epidemiology and Biostatistics, George Washington University Biostatistics Center, Washington, Disctrict of Columbia.
Dwight J RouseDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Brian M MercerDepartment of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Kenneth J LevenoDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
Uma M ReddyEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Catalin BuhimschiDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio.
Ronald J WapnerDepartment of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Yoram SorokinDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.
John M ThorpDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Susan M RaminDepartment of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas.
Fergal D MaloneDepartment of Obstetrics and Gynecology, Columbia University, New York, New York.
Marshall CarpenterDepartment of Obstetrics and Gynecology, Brown University, Providence, Rhode Island.
Mary J O'sullivanDepartment of Obstetrics and Gynecology, University of Miami, Miami, Florida.
Alan M PeacemanDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.
Donald J DudleyDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, Texas.
Steve N CaritisDepartment of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Brown University · USCase Western Reserve University · USColumbia University · USDrexel University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USGeorge Washington University · USNorthwestern University · USThe Ohio State University · USThe University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas Medical Branch at Galveston · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USUniversity of Utah · USWayne State University · US

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
NICHD Maternal Fetal Medicine Units NetworkU10HD034116 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CASEY, BRIAN M · 1996 to 2015
$19.3M
NICHD Maternal Fetal Medicine Units NetworkU10HD034208 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 1996 to 2015
$16.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 1991 to 2015
$12.8M
NICHD Maternal Fetal Medicine Units NetworkU10HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2001 to 2015
$12.5M
NICHD Maternal Fetal Medicine Units NetworkU10HD040560 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THORP, JOHN M · 2001 to 2015
$10.3M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD040512 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2001 to 2015
$8.7M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS M01 RR000080NICHD NIH HHS P2C HD050924NICHD NIH HHS U01 HD019897NICHD NIH HHS U01 HD036801NICHD NIH HHS U10 HD021410NICHD NIH HHS U10 HD027860NICHD NIH HHS U10 HD027869NICHD NIH HHS U10 HD027905NICHD NIH HHS U10 HD027915NICHD NIH HHS U10 HD027917NICHD NIH HHS U10 HD034116NICHD NIH HHS U10 HD034122NICHD NIH HHS U10 HD034136NICHD NIH HHS U10 HD034208NICHD NIH HHS U10 HD036801NICHD NIH HHS U10 HD040485NICHD NIH HHS U10 HD040500NICHD NIH HHS U10 HD040512NICHD NIH HHS U10 HD040544NICHD NIH HHS U10 HD040545NICHD NIH HHS U10 HD040560NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034116NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097
6 · The paper itself

Abstract

objectiveTo evaluate sex-specific genetic susceptibility to adverse neurodevelopmental outcome (ANO, defined as cerebral palsy [CP], mental, or psychomotor delay) at risk for early preterm birth (EPTB, < 32 weeks). STUDY

designSecondary case-control analysis of a trial of magnesium sulfate (MgSO

resultsAnalysis included 211 cases (134 males; 77 females) and 213 controls (130 males; 83 females). An interleukin-6 (IL6) polymorphism (rs2069840) was associated with ANO in females (OR: 2.6, 95% confidence interval [CI]: 1.5-4.7;

conclusionAn

Indexed as

Genetic Predisposition to DiseaseCase-Control StudiesCerebral PalsyFemaleHumansInfantInterleukin-6Logistic ModelsMagnesium SulfateMaleNeurodevelopmental DisordersPolymorphism, Single NucleotidePregnancyPremature BirthPsychomotor DisordersSex FactorsInterleukin-6Magnesium SulfateTocolytic Agents

Identifiers

PMID30731481
PMCPMC6685763
OpenAlexW2914233056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.