ArticleLife sciences2019
Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction.
Article in Life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies.Cardiovascular research · 2023Pooled it
- Blueprint of the distinct metabolite profiles of healthy pig heart chambers.Journal of molecular and cellular cardiology plus · 2025Article
- Novel cardiac biomarkers and multiple-marker approach in the early detection, prognosis, and risk stratification of cardiac diseases.World journal of cardiology · 2025Review
- Recent progress in metabolomic analysis of acute coronary syndrome: a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction.Scientific reports · 2024Article
- Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction.Scientific reports · 2024Article
- Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models.PloS one · 2023Article
- From multi-omics approaches to personalized medicine in myocardial infarction.Frontiers in cardiovascular medicine · 2023Review
- Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease.Nature cardiovascular research · 2023Article
- Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure.Frontiers in cardiovascular medicine · 2022Article
- Impact of Myocardial Energy Expenditure and Diastolic Dysfunction on One Year Outcome Patients With HFpEF.Frontiers in physiology · 2022Article
- Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels.PloS one · 2020Article
- Proteomic and metabolomic characterization of cardiac tissue in acute myocardial ischemia injury rats.PloS one · 2020Article
- Shenmai Injection Improves Energy Metabolism in Patients With Heart Failure: A Randomized Controlled Trial.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo determine the metabolic adaptations to compensated heart failure using a reproducible model of myocardial infarction and an unbiased metabolic screen. To address the limitations in sample availability and model variability observed in preclinical and clinical metabolic investigations of heart failure. MAIN
methodsMetabolomic analysis was performed on serum and myocardial tissue from rabbits after myocardial infarction (MI) was induced by cryo-injury of the left ventricular free wall. Rabbits followed for 12 weeks after MI exhibited left ventricular dilation and depressed systolic function as determined by echocardiography. Serum and tissue from the viable left ventricular free wall, interventricular septum and right ventricle were analyzed using a gas chromatography time of flight mass spectrometry-based untargeted metabolomics assay for primary metabolites. KEY
findingsUnique results included: a two- three-fold increase in taurine levels in all three ventricular regions of MI rabbits and similarly, the three regions had increased inosine levels compared to sham controls. Reduced myocardial levels of myo-inositol in the myocardium of MI animals point to altered phospholipid metabolism and membrane receptor function in heart failure. Metabolite profiles also provide evidence for responses to oxidative stress and an impairment in TCA cycle energy production in the failing heart. SIGNIFICANCE: Our results revealed metabolic changes during compensated cardiac dysfunction and suggest potential targets for altering the progression of heart failure.
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Registered trials
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