Evidence map›Paper›PMID 30731079›Full record

ArticleChemico-biological interactions2019

Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient dams.

Lizhi Wu, Natalia Y Kedishvili, Olga V Belyaeva

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lizhi WuDepartment of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Natalia Y KedishviliDepartment of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Olga V BelyaevaDepartment of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. Electronic address: obeliaeva@uab.edu.
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
SHORT-CHAIN DEHYDROGENASES IN RETINOL/STEROL METABOLISMR01AA012153 · NIAAA · UNIVERSITY OF MISSOURI KANSAS CITY · PI KEDISHVILI, NATALIA Y · 2000 to 2017
$5.1M
NCI NIH HHS P30 CA013148NIAAA NIH HHS R01 AA012153
6 · The paper itself

Abstract

Retinol dehydrogenase 11 (RDH11) is an NADPH-dependent retinaldehyde reductase that was previously reported to function in the visual cycle. Recently, we have shown that RDH11 contributes to the maintenance of retinol levels in extraocular tissues under conditions of vitamin A deficiency or reduced vitamin A availability. RDH11 is also expressed in the embryo. Rdh11 knockout animals do not display embryonic defects and appear to develop normally to the adult stage, but the exact function of RDH11 during development is not yet known. In contrast to RDH11-null mice, animals that lack dehydrogenase/reductase 3 (DHRS3), the enzyme that functions as a retinaldehyde reductase and is essential for the maintenance of retinoid homeostasis during embryogenesis, rarely survive until birth. Here, we investigated whether inactivation of RDH11 together with DHRS3 exacerbates the severity of retinoid homeostasis disruption in embryos that lack both enzymes compared to DHRS3-null mice. The results of this study indicate that in vitamin A sufficient animals, the loss of RDH11 in addition to DHRS3 does not appear to significantly impact the total levels of retinoic acid, free retinol, or retinyl esters in Rdh11

Indexed as

Alcohol OxidoreductasesAnimalsChromatography, High Pressure LiquidEmbryo, MammalianEstersMiceMice, KnockoutOxidoreductasesRetinaldehydeRetinoidsTretinoinVitamin AAlcohol OxidoreductasesDHRS3 protein, mouseEstersOxidoreductasesRdh11 protein, mouseRetinaldehydeRetinoidsTretinoinVitamin A

Identifiers

PMID30731079
PMCPMC6506212
OpenAlexW2913000402

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.