ArticlePloS one2019
Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells.JCI insight · 2026Article
- A risk prediction model based on immune-inflammatory-nutritional indicators for predicting 28-day mortality in sepsis patients with acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
- Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality.PloS one · 2026Article
- The interplay between recovery and immunity in infectious and non-communicable diseases.Frontiers in cellular and infection microbiology · 2026Review
- Predictive Value of the Neutrophil‒Lymphocyte Ratio in the Risk Stratification and Prognosis for Patients with Acute Cholangitis: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Molecular analysis of immune cell subsets and cytokine profiles in septic Vietnamese patients.Clinical and experimental medicine · 2025Article
- The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury.Scientific reports · 2025Article
- Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets.Aging and disease · 2025Review
- Potential of interleukin-7 in sepsis as a biomarker and therapeutic agent: a narrative review.Frontiers in medicine · 2025Review
- Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population ofFrontiers in immunology · 2025Article
- Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations.Military Medical Research · 2024Review
- Lymphopenia in sepsis: a narrative review.Critical care (London, England) · 2024Review
- Prognostic impacts of repeated sepsis in intensive care unit on autoimmune disease patients: a retrospective cohort study.BMC infectious diseases · 2024Article
- Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.Frontiers in immunology · 2024Observational
- Analysis of bulk RNA-seq data from sepsis patients reveals sepsis-associated lncRNAs and targeted cell death-related genes contributing to immune microenvironment regulation.Frontiers in immunology · 2023Article
- Immune modulation after traumatic brain injury.Frontiers in medicine · 2022Review
- Acute decompensation events differentially impact the risk of nosocomial infections and short-term outcomes in patients with cirrhosis.Frontiers in medicine · 2022Article
- Metagenomic evidence for a polymicrobial signature of sepsis.Microbial genomics · 2021Article
- The IL-27 receptor regulates TIGIT on memory CD4iScience · 2021Article
- Identification of Potential Early Diagnostic Biomarkers of Sepsis.Journal of inflammation research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive apoptosis of lymphocytes is a hallmark of sepsis. The resulting immunosuppression is associated with secondary infections, which are often lethal. Moreover, sepsis-survivors are burdened with increased morbidity and mortality for several years after the sepsis episode. The duration and clinical consequences of sepsis induced-immunosuppression are currently unknown. We have used the mouse model of peritoneal contamination and infection (PCI) to investigate the quantitative and qualitative recovery of T lymphocytes for 3.5 months after sepsis with or without IL-7 treatment. Thymic output and the numbers of naive and effector/memory CD4+ and CD8+ lymphocytes quickly recovered after sepsis. IL-7 treatment resulted in an accelerated recovery of CD8+ lymphocytes. Next generation sequencing revealed no significant narrowing of the T cell receptor repertoire 3.5 months after sepsis. In contrast, detailed functional analyses of T helper (Th)-cell responses towards a fungal antigen revealed a significant loss of Th cells. Whereas cytokine production was not impaired at the single cell level, the absolute number of Th cells specific for the fungal antigen was reduced. Our data indicate a clinically relevant loss of pathogen-specific T cell clones after sepsis. Given the small number of naive T lymphocytes specific for a given antigen, this decrement of T cell clones remains undetected even by sensitive methods such as deep sequencing. Taken together, our data are compatible with long lasting impairments in CD4+ T-cell responses after sepsis despite rapid recovery of T lymphocyte populations.
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