ArticlePloS one2019
Diet influences the bacterial and free fatty acid profiles of the cuticle of Galleria mellonella larvae.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- The use of Galleria mellonella to study microbial interactions, immune responses, and substrate interactions.Essays in biochemistry · 2026Review
- Camelina and linseed cakes for yellow mealworm larvae: Effects on productive performance and nutritional composition.Veterinary and animal science · 2026Article
- Microbial Succession on Honey Bee Body Surfaces Reflects Behavioral Maturation.Microorganisms · 2026Article
- Insects as a New Source of Plant Growth Promoting Bacteria - Review.Microbial ecology · 2026Review
- Biotransformation of Canola Feedstock Waste Using Brassica Pest Microbiome: Proof of Concept for Insects as Bioengineers.International journal of molecular sciences · 2025Article
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- Effect of Benzyl Alcohol on Main Defense System Components ofInternational journal of molecular sciences · 2024Article
- Hemp regulates the fitness of corn earworm (Lepidoptera, Noctuidae) and its tachinid (Diptera) parasitoids.PloS one · 2024Article
- Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on theFrontiers in cellular and infection microbiology · 2024Article
- Functional insights of three RING-finger peroxins in the life cycle of the insect pathogenic fungus Beauveria bassiana.Current genetics · 2023Article
- The Entomopathogenic FungusInsects · 2023Article
- Using theMicrobiology (Reading, England) · 2023Article
- The lipidome of an omnivorous insect responds to diet composition and social environment.Ecology and evolution · 2022Article
- Peroxins in Peroxisomal Receptor Export System Contribute to Development, Stress Response, and Virulence of Insect Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Octanoic Acid-An Insecticidal Metabolite ofInternational journal of molecular sciences · 2022Article
- The Impact of the Entomopathogenic FungusInsects · 2021Article
- Dodecanol, metabolite of entomopathogenic fungus Conidiobolus coronatus, affects fatty acid composition and cellular immunity of Galleria mellonella and Calliphora vicina.Scientific reports · 2021Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary success of insects is arguably due to their ability to build up a complex, highly-adaptable and very effective defense system against numerous pathogens, including entomopathogenic fungi. This system relies on the humoral immune system and cellular defense reactions. The first line of defense against biological pathogens is a cuticle formed of several layers. The cuticular lipids may contain hydrocarbons, free fatty acids (FFA), alcohols, waxes, glycerides, aldehydes and sterols. Cuticular fatty acids may also play a role in defending against fungal invasion. Our present findings show that the diet of insects can have a significant effect on their sensitivity and defense response to pathogens; for example, while G. mellonella larvae fed on beeswax had a similar appearance to those reared on a semi-artificial diet, they possessed a different cuticular free fatty acid (FFA) profile to those fed on a semi-artificial diet, and were less sensitive to Conidiobolus coronatus infection. It is possible that the presence of heneicosenoic acid (C21:1) and other long-chain free fatty acids (C22:0, C24:0, C26:0), as well as Brevibacillus laterosporus bacteria, on the cuticle of larvae fed on beeswax, plays a protective role against fungal invasion. Insect pests represent a global problem. An understanding of the basic mechanisms underlying the fungal infection of insects might provide a clearer insight into their defenses, thus allowing the design of more effective, and environmentally-friendly, means of controlling them. The greater wax moth is an excellent model for the study of immunology resistance. Knowledge of the influence of diet on pathogen resistance in insects can be also useful for creating a model of human diseases caused by pathogens, such as Candia albicans.
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Registered trials
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