ArticlePLoS biology2019
Evolutionary change in the human gut microbiome: From a static to a dynamic view.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Gut microbiota, nutrition, and mental health.Frontiers in nutrition · 2024Review
- Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse Model to Study Microbiome Function.mSystems · 2022Article
- Evolutionary Pathways and Trajectories in Antibiotic Resistance.Clinical microbiology reviews · 2021Article
- Molecular signatures of resource competition: Clonal interference favors ecological diversification and can lead to incipient speciation.Evolution; international journal of organic evolution · 2021Article
- Altered gut ecosystems plus the microbiota's potential for rapid evolution: A recipe for inevitable change with unknown consequences.Computational and structural biotechnology journal · 2021Review
- The microbiota-microglia axis in central nervous system disorders.Brain pathology (Zurich, Switzerland) · 2020Review
- Modulating the Intestinal Microbiota: Therapeutic Opportunities in Liver Disease.Journal of clinical and translational hepatology · 2020Review
- Linking gut microbiota with the human diseases.Bioinformation · 2020Article
- Health impact of the Anthropocene: the complex relationship between gut microbiota, epigenetics, and human health, using obesity as an example.Global health, epidemiology and genomics · 2020Review
- The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis.Frontiers in endocrinology · 2020Review
- Microbial evolution and ecological opportunity in the gut environment.Proceedings. Biological sciences · 2019Article
- Gene Transmission in the One Health Microbiosphere and the Channels of Antimicrobial Resistance.Frontiers in microbiology · 2019Review
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Abstract
Our intestine is a melting pot of interactions between microbial and human cells. This gene-rich ecosystem modulates our health, but questions remain unanswered regarding its genetic structure, such as, "How rapid is evolutionary change in the human gut microbiome? How can its function be maintained?" Much research on the microbiome has characterized the species it contains. Yet the high growth rate and large population sizes of many species, and the mutation rate of most microbes (approximately 10-3 per genome per generation), could imply that evolution might be happening in our gut along our lifetime. In support of this view, Garud and colleagues present an analysis that begins to unravel the pattern of short- and long-term evolution of dozens of gut species. Even with limited longitudinal short-read sequence data, significant evolutionary dynamics-shaped by both positive and negative selection-can be detected on human microbiomes. This may only be the tip of the iceberg, as recent work on mice suggests, and its full extent should be revealed with dense time series long-read sequence data and new eco-evolutionary theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.