Trial reportPloS one2019
A guide for using NIH Image J for single slice cross-sectional area and composition analysis of the thigh from computed tomography.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults
Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients.Frontiers in nutrition · 2022Pooled it
- Muscle mass and quality by computed tomography predicts mortality and emergency department revisits in older adults with acute pulmonary embolism.Journal of thrombosis and thrombolysis · 2026Article
- Characterization of body composition dynamics throughout treatment in patients with early-stage breast cancer.NPJ breast cancer · 2026Article
- Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis.Scientific reports · 2026Article
- Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges.Journal of cachexia, sarcopenia and muscle · 2026Review
- Rectus femoris ultrasound identifies sarcopenia and predicts poor outcomes in patients with acute decompensation of cirrhosis.JHEP reports : innovation in hepatology · 2025Article
- Association Between Sarcopenia Measured by Computed Tomography at the Third Lumbar Vertebra and Mortality in Inpatients with Delirium Referred to a Liaison Psychiatry Team: A Follow-Up Study.Journal of clinical medicine · 2025Article
- Impact of Muscle Quality on Muscle Strength and Physical Performance Beyond Muscle Mass or Diabetes Status.Journal of cachexia, sarcopenia and muscle · 2025Article
- Relationship between visceral obesity and prognosis in patients with stage IVB cervical cancer receiving radiotherapy and chemotherapy.Cancer pathogenesis and therapy · 2024Article
- Low muscle density in children with osteogenesis imperfecta using opportunistic low-dose chest CT: a case-control study.BMC musculoskeletal disorders · 2024Article
- One-leg standing time is a simple measure for loss of skeletal muscle mass and fat deposition in muscle: the J-SHIPP study.Aging clinical and experimental research · 2024Article
- Deep learning-based respiratory muscle segmentation as a potential imaging biomarker for respiratory function assessment.PloS one · 2024Article
- A Multimodal Approach to Quantify Chondrocyte Viability for Airway Tissue Engineering.The Laryngoscope · 2023Article
- Article
- Impact of sarcopenia on tumor response and survival outcomes in patients with hepatocellular carcinoma treated by trans-arterial (chemo)-embolization.World journal of gastroenterology · 2022Article
- Temporal Changes in Subcutaneous Fibrosis in Patients with Lower Extremity Lymphedema Following Surgery for Gynecologic Cancer: A Computed Tomography-Based Quantitative Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis.Journal of visualized experiments : JoVE · 2022Article
- A reliable and robust method for the upper thigh muscle quantification on computed tomography: toward a quantitative biomarker for sarcopenia.BMC musculoskeletal disorders · 2022Article
- Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Reports using computed tomography (CT) to estimate thigh skeletal muscle cross-sectional area and mean muscle attenuation are often difficult to evaluate due to inconsistent methods of quantification and/or poorly described analysis methods. This CT tutorial provides step-by-step instructions in using free, NIH Image J software to quantify both muscle size and composition in the mid-thigh, which was validated against a robust commercially available software, SliceOmatic. CT scans of the mid-thigh were analyzed from 101 healthy individuals aged 65 and older. Mean cross-sectional area and mean attenuation values are presented across seven defined Hounsfield unit (HU) ranges along with the percent contribution of each region to the total mid-thigh area. Inter-software correlation coefficients ranged from R2 = 0.92-0.99 for all specific area comparisons measured using the Image J method compared to SliceOmatic. We recommend reporting individual HU ranges for all areas measured. Although HU range 0-100 includes the majority of skeletal muscle area, HU range -29 to 150 appears to be the most inclusive for quantifying total thigh muscle. Reporting all HU ranges is necessary to determine the relative contribution of each, as they may be differentially affected by age, obesity, disease, and exercise. This standardized operating procedure will facilitate consistency among investigators reporting computed tomography characteristics of the thigh on single slice images. Trial Registration: ClinicalTrials.gov NCT02308228.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.