ArticlePLoS biology2019
Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The emergence of the ectodysplasin pathway.Open life sciences · 2026Article
- Six million years of vole dental evolution shaped by tooth development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation.Nature communications · 2025Article
- PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.Current biology : CB · 2025Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish.Development (Cambridge, England) · 2023Article
- Bat teeth illuminate the diversification of mammalian tooth classes.Nature communications · 2023Article
- What sharks and mammals share.eLife · 2022Article
- Stripe and spot selection in cusp patterning of mammalian molar formation.Scientific reports · 2022Article
- An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.eLife · 2022Article
- Elevated WNT signaling and compromised Hedgehog signaling due toFrontiers in dental medicine · 2022Article
- Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.Development (Cambridge, England) · 2021Article
- Folding Stability of Pax9 Intronic G-Quadruplex Correlates with Relative Molar Size in Eutherians.Molecular biology and evolution · 2021Article
- The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction-diffusion system.Scientific reports · 2021Article
- Regulatory role of insulin-like growth factor-binding proteins in odontogenic mineralization in rats.Journal of molecular histology · 2021Article
- Hypoxia-Responsive Oxygen Nanobubbles for Tissues-Targeted Delivery in Developing Tooth Germs.Frontiers in cell and developmental biology · 2021Article
- Review
- Exerting an influence on evolution.eLife · 2020Article
- Article
- Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.Frontiers in cell and developmental biology · 2020Article
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10 authors.
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Abstract
When patterns are set during embryogenesis, it is expected that they are straightly established rather than subsequently modified. The patterning of the three mouse molars is, however, far from straight, likely as a result of mouse evolutionary history. The first-formed tooth signaling centers, called MS and R2, disappear before driving tooth formation and are thought to be vestiges of the premolars found in mouse ancestors. Moreover, the mature signaling center of the first molar (M1) is formed from the fusion of two signaling centers (R2 and early M1). Here, we report that broad activation of Edar expression precedes its spatial restriction to tooth signaling centers. This reveals a hidden two-step patterning process for tooth signaling centers, which was modeled with a single activator-inhibitor pair subject to reaction-diffusion (RD). The study of Edar expression also unveiled successive phases of signaling center formation, erasing, recovering, and fusion. Our model, in which R2 signaling center is not intrinsically defective but erased by the broad activation preceding M1 signaling center formation, predicted the surprising rescue of R2 in Edar mutant mice, where activation is reduced. The importance of this R2-M1 interaction was confirmed by ex vivo cultures showing that R2 is capable of forming a tooth. Finally, by introducing chemotaxis as a secondary process to RD, we recapitulated in silico different conditions in which R2 and M1 centers fuse or not. In conclusion, pattern formation in the mouse molar field relies on basic mechanisms whose dynamics produce embryonic patterns that are plastic objects rather than fixed end points.
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