Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2019
Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Effects of breaking up prolonged sitting on vascular endothelial function in adults: a systematic review.Frontiers in cardiovascular medicine · 2026Pooled it
- Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.BMC psychiatry · 2025Pooled it
- Effect of Exercise Prior to Sedentary Behavior on Vascular Health Parameters: A Systematic Review and Meta-Analysis of Crossover Trials.Sports medicine - open · 2024Pooled it
- Acute effects of sedentary breaks on vascular health in adults at risk for type 2 diabetes: A systematic review.Vascular medicine (London, England) · 2021Pooled it
- Interventions for reducing sedentary behaviour in community-dwelling older adults.The Cochrane database of systematic reviews · 2021Pooled it
- Trial
- Secondary analysis of a randomised controlled trial on reducing sedentary behaviour and its effects on quality of life and wellbeing.Scientific reports · 2025Trial
- The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults.Nutrients · 2025Trial
- Interrupting sitting with moderate-intensity physical activity breaks improves cognitive processing speed in adults with overweight and obesity: Findings from the SITLess pilot randomized crossover trial.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Trial
- The effects of equine-assisted activities on execution function in children aged 7-8 years: A randomized controlled trial.Brain and behavior · 2023Trial
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Effects of 5-Minute Light-Intensity Physical Activity Breaks (Sit-Cycling and Stand-Twisting) on Cognitive Function, Sleepiness, and Back Pain in Physically Inactive University Students: Protocol for a Mixed-Design Laboratory Study.JMIR research protocols · 2026Article
- Exercise timing as a potential temporal regulator of neurolymphatic physiology in neurodegenerative proteinopathies: a mechanistic framework.Frontiers in neuroscience · 2026Review
- Exercise snacks and cognitive health in older adults: mechanisms, implementation, and public health relevance.Frontiers in public health · 2026Review
- Short bouts of accumulated exercise: Review and consensus statement on definition, efficacy, feasibility, practical applications, and future directions.Journal of sport and health science · 2025Article
- Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.Physiological reports · 2025Article
- From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience.Frontiers in aging neuroscience · 2025Review
- Effect of prolonged sitting on dynamic cerebral autoregulation in the anterior and posterior cerebral circulations.Experimental physiology · 2025Article
- Sedentary Behaviors, Light-Intensity Physical Activity, and Healthy Aging.JAMA network open · 2024Article
- Sedentary behavior and lifespan brain health.Trends in cognitive sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preventing declines in cerebral blood flow is important for maintaining optimal brain health with aging. We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cerebral blood velocity over 8 h in older adults. In a randomized crossover trial, overweight/obese older adults ( n = 12, 70 ± 7 yr; 30.4 ± 4.3 kg/m
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.