ArticleGlia2019
Structurally defined signaling in neuro-glia units in the enteric nervous system.
Article in Glia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Global research status and trends of enteric glia: a bibliometric analysis.Frontiers in pharmacology · 2024Pooled it
- Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Molecular Diversity and Functional Implications of Mammalian Choline Acetyltransferases in Neuronal and Non-Neuronal Cells.International journal of molecular sciences · 2026Review
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- Support Cells to Stem Cells: The Promise of Enteric Glia in Treating Gut Neuropathies.Cellular and molecular gastroenterology and hepatology · 2026Article
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Enteric glia and purinergic signaling in health and disease.Neuropharmacology · 2025Review
- The role of reactive enteric glia-macrophage interactions in acute and chronic inflammation.Neurogastroenterology and motility · 2025Review
- Genomic stress in diseases stemming from defects in the second brain.Neurogastroenterology and motility · 2025Review
- Muscarinic Receptor-Mediated Electroacupuncture Modulation of Reactive Enteric Glial Cells Ameliorates Postoperative Ileus.Journal of inflammation research · 2025Article
- Imaging the enteric nervous system.Frontiers in neuroanatomy · 2025Review
- TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.bioRxiv : the preprint server for biology · 2024Article
- Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity.Frontiers in immunology · 2024Article
- From diversity to disease: unravelling the role of enteric glial cells.Frontiers in immunology · 2024Review
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.Journal of neuroinflammation · 2023Article
- Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS · 2023Article
- Mini-review: Intercellular communication between enteric glia and neurons.Neuroscience letters · 2023Review
- The enteric nervous system.Physiological reviews · 2023Review
- Temporal transcriptome profiling of floating apical out chicken enteroids suggest stability and reproducibility.Veterinary research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordination of gastrointestinal function relies on joint efforts of enteric neurons and glia, whose crosstalk is vital for the integration of their activity. To investigate the signaling mechanisms and to delineate the spatial aspects of enteric neuron-to-glia communication within enteric ganglia we developed a method to stimulate single enteric neurons while monitoring the activity of neighboring enteric glial cells. We combined cytosolic calcium uncaging of individual enteric neurons with calcium imaging of enteric glial cells expressing a genetically encoded calcium indicator and demonstrate that enteric neurons signal to enteric glial cells through pannexins using paracrine purinergic pathways. Sparse labeling of enteric neurons and high-resolution analysis of the structural relation between neuronal cell bodies, varicose release sites and enteric glia uncovered that this form of neuron-to-glia communication is contained between the cell body of an enteric neuron and its surrounding enteric glial cells. Our results reveal the spatial and functional foundation of neuro-glia units as an operational cellular assembly in the enteric nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.