ArticleThe Clinical journal of pain2019
Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain.
Article in The Clinical journal of pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between posttraumatic stress disorder and migraine: A systematic review.Headache · 2026Pooled it
- Co-Occurring Trauma and Non-Suicidal Self-Injury Among People With Chronic Pain: A Systematic Review.Current pain and headache reports · 2021Pooled it
- Stepped collaborative care for pain and posttraumatic stress disorder after major trauma: a randomized controlled feasibility trial.Disability and rehabilitation · 2024Trial
- Outcomes of patients with post-traumatic stress disorder following arthroscopic rotator cuff repair.JSES reviews, reports, and techniques · 2026Article
- Associations between PTSD symptom clusters and multi-region pain in young adults with chronic pain.Journal of behavioral medicine · 2026Article
- Do Injury, Depression, and PTSD Mediate the Relationships Between Latent Profiles of Cumulative Lifetime Violence and Chronic Pain Disability in Men?Research in nursing & health · 2026Article
- A Mixed-Methods Examination of Interdisciplinary Strategies for Addressing Trauma and Chronic Pain in Group Therapy.Healthcare (Basel, Switzerland) · 2026Article
- Central Sensitisation After Orthopaedic Trauma: An Overlooked Contributor to Chronic Pain and Functional Disability-A Scoping Review.Journal of clinical medicine · 2026Review
- The COMPASS framework for chronic pain and posttraumatic stress disorder: navigating the transition from threat to safety through yoga.Frontiers in public health · 2026Article
- The lived and living experiences of having chronic pain and mental illness among Canadian veterans: A qualitative descriptive study.PLOS mental health · 2026Article
- The pain of PTSD: integrating persistent or chronic pain within emotional processing theory of posttraumatic stress disorder.European journal of psychotraumatology · 2025Article
- Trauma and psychological impact in fibromyalgia and other central sensitization syndromes: the role of anxiety and pain acceptance.BMC psychology · 2025Article
- Central Sensitization Syndromes and Trauma: Mediating Role of Sleep Quality, Pain Catastrophizing, and Emotional Dysregulation Between Post-Traumatic Stress Disorder and Pain.Healthcare (Basel, Switzerland) · 2025Article
- Grit and Chronic Pain: Associations with Distress, Catastrophizing, Interference, and Control.Journal of clinical psychology in medical settings · 2025Article
- Central Sensitivity Symptoms and Autistic Traits in Autistic and Non-Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2025Article
- Negative affect and pain catastrophizing link borderline personality disorder to pain: Replicating and extending the borderline personality disorder-pain association.Personality disorders · 2025Article
- Profiles of Trauma Exposure Type and Its Associations With Pain-Related Outcomes Among Adults With Chronic Pain: A 2-Year Longitudinal Study.The journal of pain · 2024Article
- Review
- Pain in alcohol use disorder: Evaluating effects of childhood trauma, perceived stress, and psychological comorbidity.Alcohol (Fayetteville, N.Y.) · 2024Article
- Overview: Chronic Pain and Cannabis-Based Medicines.Pharmacopsychiatry · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveEvidence supports high rates of co-occurrence of posttraumatic stress disorder (PTSD) and chronic pain disorders involving central sensitization (CS). The nature of this relationship, however, remains relatively unexplored. In this study, we aimed to (1) assess how both trauma exposure and current PTSD symptoms are related to clinical manifestations of CS, and (2) test whether PTSD symptoms explain the relationship between trauma exposure and CS. Because experiential avoidance has been shown to impact the relationship between trauma and health outcomes, we (3) explored experiential avoidance as a possible mediator or moderator of the trauma-CS relationship.
methodsA sample of 202 adult patients (79% female) with chronic pain completed validated self-report measures of trauma exposure, current PTSD symptoms, experiential avoidance, and 3 manifestations of CS: widespread pain, greater pain severity, and polysomatic symptom reporting. We used path analysis and multivariate regression to assess our study aims.
resultsBoth trauma exposure and PTSD symptoms were significantly associated with all 3 clinical indicators of CS. PTSD symptoms partially explained the relationship between trauma exposure and widespread pain, pain intensity, and polysomatic symptoms. Experiential avoidance did not mediate or moderate the trauma-CS relationship.
conclusionsOur findings suggest that trauma exposure is linked to elevated clinical markers of CS but a critical factor in this relationship is the mediating effect of current PTSD symptoms.
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