ArticleJournal of cellular and molecular medicine2019
The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.
Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Altered Gas6/sMerTK Balance in Gingival Crevicular Fluid Across Periodontal Health, Gingivitis, and Periodontitis: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- TAM pathway proteins as novel salivary biomarkers for periodontitis.Journal of periodontology · 2026Observational
- The Crosstalk Between Efferocytosis and Macrophage Polarization in Diabetic Wounds: A Comprehensive Review.Journal of inflammation research · 2026Review
- LAX1 as a core biomarker in Alzheimer's disease and periodontitis via the STAT signaling pathway.BMC geriatrics · 2025Article
- TAM Pathway Receptor Proteins: Differential Expression in Healthy Human Masticatory Mucosa.Journal of periodontal research · 2025Article
- Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors and is Required for Placenta Morphogenesis and Vasculature Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Role of TAM Receptors in Bone.International journal of molecular sciences · 2023Review
- Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants.Pharmaceuticals (Basel, Switzerland) · 2023Article
- LncRNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated low PROS1 expression is an onco-immunological biomarker in low-grade gliomas: a pan-cancer analysis with experimental verification.Journal of translational medicine · 2022Article
- Armed to the Teeth-The Oral Mucosa Immunity System and Microbiota.International journal of molecular sciences · 2022Review
- Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.Journal of clinical laboratory analysis · 2022Article
- PROS1 shapes the immune-suppressive tumor microenvironment and predicts poor prognosis in glioma.Frontiers in immunology · 2022Article
- STAT1/SOCS1/3 Are Involved in the Inflammation-Regulating Effect of GAS6/AXL in Periodontal Ligament Cells Induced byJournal of immunology research · 2021Article
- CD14Arthritis research & therapy · 2020Article
- Crosstalk between Akt and NF-κB pathway mediates inhibitory effect of gas6 on monocytes-endothelial cells interactions stimulated by P. gingivalis-LPS.Journal of cellular and molecular medicine · 2020Article
- Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis.Journal of immunology research · 2020Article
- The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.Journal of cellular and molecular medicine · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis, an oral inflammatory disease caused by periodontal pathogen infection, is the most prevalent chronic inflammatory disease and a major burden on healthcare. The TAM receptor tyrosine kinases (Tyro3, Axl and Mertk) and their ligands (Gas6 and Pros1) play a pivotal role in the resolution of inflammation and have been associated with chronic inflammatory and autoimmune diseases. In this study, we evaluated the effects of exogenous Pros1 in in vitro and in vivo models of periodontitis. We detected higher Pros1 but lower Tyro3 levels in inflamed gingival specimens of periodontitis patients compared with healthy controls. Moreover, Pros1 was mostly localized in the gingival epithelium of all specimens. In cultured human gingival epithelial cells (hGECs), Porphyromonas gingivalis LPS (p.g-LPS) stimulation down-regulated Pros1 and Tyro3. Exogenous Pros1 inhibited p.g-LPS-induced production of TNF-α, IL-6, IL-1β, MMP9/2 and RANKL in a Tyro3-dependent manner as revealed by PCR, Western blot analysis, ELISA and gelatin zymography. Pros1 also restored Tyro3 expression down-regulated by p.g-LPS in hGECs. In rats treated with ligature and p.g-LPS, administration of Pros1 attenuated periodontitis-associated gingival inflammation and alveolar bone loss. Our mechanistic studies implicated SOCS1/3 and STAT1/3 as mediators of the in vitro and in vivo anti-inflammatory effects of Pros1. Collectively, the findings from this work supported Pros1 as a novel anti-inflammatory therapy for periodontitis.
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