Evidence map›Paper›PMID 30729542›Full record

SynthesisJournal of surgical oncology2019

Perioperative and oncological outcomes of abdominoperineal resection in the prone position vs the classic lithotomy position: A systematic review with meta-analysis.

Jose Wilson B Mesquita-Neto, Hassan Mouzaihem, Francisco Igor B Macedo, Lance K Heilbrun, Donald W Weaver, Steve Kim

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jose Wilson B Mesquita-NetoDepartment of Surgery, Barbara-Ann Karmanos Comprehensive Cancer Center, Detroit Medical Center/Wayne State University School of Medicine, Detroit, Michigan.ORCID http://orcid.org/0000-0001-8673-1741
Hassan MouzaihemDepartment of Surgery, Barbara-Ann Karmanos Comprehensive Cancer Center, Detroit Medical Center/Wayne State University School of Medicine, Detroit, Michigan.
Francisco Igor B MacedoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.ORCID http://orcid.org/0000-0003-3979-6504
Lance K HeilbrunDepartment of Biostatistics, Barbara-Ann Karmanos Comprehensive Cancer Center, Detroit Medical Center/Wayne State University School of Medicine, Detroit, Michigan.
Donald W WeaverDepartment of Surgery, Barbara-Ann Karmanos Comprehensive Cancer Center, Detroit Medical Center/Wayne State University School of Medicine, Detroit, Michigan.
Steve KimDepartment of Surgery, Barbara-Ann Karmanos Comprehensive Cancer Center, Detroit Medical Center/Wayne State University School of Medicine, Detroit, Michigan.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
NCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThis study is a systematic review with meta-analysis designed to compare the perioperative and oncological outcomes of the abdominoperineal resection (APR) carried out in the prone jack-knife position (P-APR) vs the classic lithotomy position (C-APR).

methodsWe conducted an electronic search through PubMed utilizing the PRISMA guidelines. We included all randomized and nonrandomized studies which allowed for comparative analysis between the two groups. Research that focused on and analyzed the extralevator abdominal excision were excluded. Pooled variables and number of events were analyzed using the random-effect model.

resultsThe final analysis included seven nonrandomized retrospective cohorts encompassing 1663 patients. P-APR was associated with decreased operative time (OT) (DM, -43.8 minutes; P < 0.01) and estimated blood loss (EBL) (DM, 86.9 mL; P < 0.01). There were no observed differences regarding perineal wound infections (PWI) (odds ratio [OR], 0.36; P = 0.18), intraoperative perforation of rectum (IOP) (OR, 0.98; P = 0.97), circumferential resection margin (CRM) positivity (OR, 1.02; P = 0.98) or 5-year LR (OR, 1.00; P = 0.99).

conclusionThe prone approach for APR is associated with decreased EBL and OT, although not with any change in the incidence of PWI or IOP. Moreover, surgical positioning per se does not appear to affect the CRM positivity rates or LR rate.

Indexed as

HumansMargins of ExcisionPatient PositioningProctectomyProne PositionRandomized Controlled Trials as TopicRectal NeoplasmsRetrospective StudiesTreatment Outcomeabdominoperineal resectionprognosisrectal cancerresection marginssurgery

Identifiers

PMID30729542
PMCPMC6844252

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.