SynthesisProbiotics and antimicrobial proteins2020
Probiotics as an Adjunct Therapy for the Treatment of Halitosis, Dental Caries and Periodontitis.
Synthesis in Probiotics and antimicrobial proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy: a Randomized Controlled Trial.
Evaluating Safety and Efficacy of Oral-Spray Bacillus Probiotic (LiveSpo® Smile CARE) in the Prevention and Adjunctive Treatment of Dental Caries in Children
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Caries prevention in permanent teeth - basic recommendations of the German S 3 guideline.Clinical oral investigations · 2026Guideline
- Therapeutic Strategies and Genetic Implications for Periodontal Disease Management: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- The efficacy of probiotics in the management of intra-oral halitosis: a systematic review.Clinical oral investigations · 2022Pooled it
- Impact of oral probiotics on oral health and halitosis in orthodontic patients treated with aligners or conventional fixed appliances vs placebo: two randomized clinical trials.European journal of orthodontics · 2026Trial
- A Randomized, Double-Blind, Placebo-Controlled Study on Probiotic Treatment for Halitosis: Novel Insights into Glucose and Phosphorus Metabolism.Probiotics and antimicrobial proteins · 2026Trial
- Microbiological and clinical effects of probiotic-related Zeger therapy on gingival health: a randomized controlled clinical trial.BMC oral health · 2024Trial
- Evaluation of probiotics' efficiency on cariogenic bacteria: randomized controlled clinical study.BMC oral health · 2024Trial
- Trial
- Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study.Clinical oral investigations · 2021Trial
- Mechanisms of probiotic action in poultry gut: Colonization resistance, bioactive metabolites, quorum sensing activity, and immunomodulation.Poultry science · 2026Review
- Oral Supplementation ofDentistry journal · 2026Article
- Probiotics and Ozonated Olive Oil to Maintain Oral Eubiosis in Stage I and II Periodontitis Patients: A Randomized Triple-Blind Clinical Trial.Dentistry journal · 2026Article
- Synbiotics: An Emerging Frontier in Infectious Diseases Control.Probiotics and antimicrobial proteins · 2026Review
- Shotgun metagenomic analysis of the oral microbiomes of children with noma.PLoS neglected tropical diseases · 2026Article
- Editorial: Nutrition and oral microbiology: integrative perspectives for improved oral health.Frontiers in oral health · 2026Article
- Trends and hotspots in global halitosis research: A bibliometric analysis from 2010 to 2025.Medicine · 2025Article
- Article
- Oral-Gut Microbial Crosstalk and Therapeutic Applications of Bacterial Extracellular Vesicles.Biomolecules · 2025Review
- Hydrogel Conjugation: Engineering of Hydrogels for Drug Delivery.Pharmaceutics · 2025Review
- Comparing the Inhibitory Effect of Kefir Drink and Chlorhexidine Mouthwash against Oral Bacteria in Orthodontic Patients.Journal of dentistry (Shiraz, Iran) · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics and prebiotics are popular among consumers worldwide as natural approaches to prevent gastrointestinal diseases. The effects of their consumption on the gastrointestinal system have been extensively investigated. Recently, the efficacy of probiotics and prebiotics has been evaluated against naturally developing microbiome imbalance in the human body, such as in the oral cavity, skin, female urogenital tract, and respiratory tract. This review examines the scientific data related to the effects of probiotics on the treatment of diseases occurring in the oral cavity. Probiotics can effectively prevent and treat some infectious diseases in the oral cavity, such as halitosis and periodontitis, and can reduce the development of dental caries and the concentration of harmful bacteria, according to clinical studies. The results of this meta-analysis also suggest the use of probiotics to treat halitosis and periodontitis. However, the evidence may be inconclusive due in part to the use of a wide range of probiotics, non-standardized study design, small population size, poor quality reports, and inconsistent data. Therefore, future studies should homogenize terms and definitions for primary and secondary outcomes, increase the number of volunteers/patients in in vitro tests and clinical studies, and include an evaluation of the combined use of pre- and probiotics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.