ArticleInternal and emergency medicine2019
Sepsis patients with complication of hypoglycemia and hypoalbuminemia are an early and easy identification of high mortality risk.
Article in Internal and emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- TREM2 sustains glucose metabolic homeostasis to drive antibacterial defense during sepsis.iScience · 2026Article
- Early albumin infusion and mortality in elderly patients with sepsis based on analysis of the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.Journal of Zhejiang University. Science. B · 2026Article
- Increased serum albumin corrected anion gap levels are associated with poor prognosis in sepsis-induced coagulopathy patients.PloS one · 2026Article
- Association of hypoalbuminemia and timely albumin infusion with clinical outcomes in patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Incidence and risk factor of sepsis in patients with severe community-acquired pneumonia: a Chinese, single-center, retrospective study.BMC infectious diseases · 2025Observational
- Neutrophil-to-lymphocyte-to-albumin ratio as a prognostic marker for mortality in sepsis and septic shock in Vietnam.Acute and critical care · 2025Article
- The Prognostic Value of the CALLY Index in Sepsis: A Composite Biomarker Reflecting Inflammation, Nutrition, and Immunity.Diagnostics (Basel, Switzerland) · 2025Article
- Development and validation of a multidimensional predictive model for 28-day mortality in ICU patients with bloodstream infections: a cohort study.Frontiers in cellular and infection microbiology · 2025Article
- BOBM: an adaptive deep learning framework for extended-window sepsis prediction with cross-institutional generalizability.Frontiers in medicine · 2025Article
- High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients.European journal of medical research · 2024Article
- Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study.Diabetology international · 2024Article
- Triglyceride-glucose index and clinical outcomes in sepsis: A retrospective cohort study of MIMIC-IV.Journal of cellular and molecular medicine · 2024Article
- Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders.Diagnostics (Basel, Switzerland) · 2024Article
- Predictive Value of SYN-1 Levels for Mortality in Sepsis Patients in the Emergency Department.Journal of inflammation research · 2024Article
- C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients.Renal failure · 2023Article
- Hypoglycemia measured by flash glucose monitoring system predicts liver-related events in chronic liver disease patients.Scientific reports · 2023Article
- Prognostic implication of lactic dehydrogenase-to-albumin ratio in critically ill patients with acute kidney injury.Clinical and experimental nephrology · 2023Article
- Undernutrition Scored Using the CONUT Score with Hypoglycemic Status in ICU-Admitted Elderly Patients with Sepsis Shows Increased ICU Mortality.Diagnostics (Basel, Switzerland) · 2023Article
- Expert consensus on the glycemic management of critically ill patients.Journal of intensive medicine · 2022Article
- Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Either hypoglycemia or hypoalbuminemia alone is an independent condition associated with increased risk of mortality in critical illness. This study evaluates whether the mortality risk increases in septic patients if these conditions are combined. Patients admitted to our hospital from 2008 to 2015 who satisfied the definition of sepsis were targeted (n = 336). We classified cases into three groups based on blood glucose (BG) level measured at admission: hypoglycemia (Hypo-G; BG < 80 mg/dl), intermediate glycemia (Inter-G; 80-199 mg/dl), and hyperglycemia (Hyper-G; ≥ 200 mg/dl) group, and then estimated mortality. We also compared the clinical data of these glycemic groups in combination with hypoalbuminemia (Hypo-A) or Inter-G with non-hypoalbuminemia (Inter-G + Nonhypo-A), as a secondary analysis. Diagnostic cut-off level of Hypo-A (< 2.8 mg/dl) was determined using the ROC curve between blood albumin and mortality. In Hypo-G group (n = 40), APACHE II/SOFA scores are significantly higher than in the Inter-G (n = 196) and Hyper-G groups (n = 100). Mortality is 52.5% in the Hypo-G and 60.0% in the Hypo-G with Hypo-A (Hypo-G + Hypo-A) groups. Significantly higher APACHE II or SOFA scores and mortality are observed in the Hypo-G + Hypo-A group compared to the Inter-G + Nonhypo-A group. A higher mortality risk is observed in cases with Hypo-G + Hypo-A (OR 5.065) than those with Hypo-G (OR 3.503), Inter-G (OR 1.175), Hyper-G (OR 1.756) or Hypo-A (OR 3.243), calculated by a single logistic-regression analysis. Hypo-G + Hypo-A in patients with sepsis is related to higher ICU mortality. Physicians should be keenly aware of these conditions to provide immediate intensive treatment after admission of septic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.