Evidence map›Paper›PMID 30729371›Full record

ArticleClinical rheumatology2019

Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China.

Fangran Xin, Lingyu Fu, Haina Liu, Yunwei Xu, Tingting Wei, Meng Chen

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fangran XinDepartment of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street, Shenyang, 110001, Liaoning Province, China.
Lingyu FuDepartment of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street, Shenyang, 110001, Liaoning Province, China. fulingyucmu@sina.com.
Haina LiuDepartment of Rheumatology, The First Affiliated Hospital, China Medical University, Shenyang, China.
Yunwei XuDepartment of Medical Record Management Center, The First Affiliated Hospital, China Medical University, Shenyang, China.
Tingting WeiDepartment of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street, Shenyang, 110001, Liaoning Province, China.
Meng ChenDepartment of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street, Shenyang, 110001, Liaoning Province, China.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

The prognosis risk model for rheumatoid arthritis based on integrated clinical and genetic data by using bayesian ChiCTR1800017343
6 · The paper itself

Abstract

objectivesIntend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study. MATERIALS AND

methodsClinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients.

resultsThe present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.

conclusionsA close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors.

Indexed as

AgedAged, 80 and overArthritis, RheumatoidBiomarkersBlood SedimentationBrain IschemiaChinaC-Reactive ProteinDyslipidemiasElectronic Health RecordsFemaleHumansInflammationLipidsLogistic ModelsMaleBiomarkersC-Reactive ProteinLipidsDyslipidemiaInflammatory markerRheumatoid arthritisSerum lipidsStroke

Identifiers

PMID30729371
OpenAlexW2913174446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.