SynthesisLasers in medical science2019
Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis.
Synthesis in Lasers in medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Photobiomodulation therapy on chemo- and radiotherapy induced oral conditions: an umbrella review.BMC oral health · 2024Pooled it
- Efficacy of laser therapy on primary burning mouth syndrome: a systematic review.Journal of oral & facial pain and headache · 2024Pooled it
- Impact of photobiomodulation for prevention of oral mucositis on the quality of life of patients with head and neck cancer: a systematic review.Lasers in medical science · 2023Pooled it
- Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis.International journal of environmental research and public health · 2021Pooled it
- Nutritional problems and their non-pharmacological treatment in adults undergoing haematopoietic stem cell transplantation-A systematic review.European journal of cancer care · 2020Pooled it
- Prevention and Treatment of Oral Mucositis in Pediatric Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials.In vivo (Athens, Greece)Pooled it
- Low-Level Laser Therapy, Photobiomodulation, and Photodynamics with Photosensitizer Combination in Dentistry: A Systematic Review.Journal of lasers in medical sciences · 2026Review
- Preventive Photobiomodulation for Chemotherapy-Induced Oral Mucositis: A Systematic Review of Randomized Clinical Trials.Biomedicines · 2025Review
- Incidence of oral manifestations in hematological malignancy patients undergoing chemotherapy: prospective cohort study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Photobiomodulation for the prevention and treatment of oral mucositis in patients submitted to hematopoietic stem cell transplantation: health quality evaluation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Assessing the potential efficacy of 830-nanometer low-level laser therapy in cats: Extraoral applications.Veterinary world · 2024Article
- Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients.Biomolecules · 2023Review
- Article
- Non-thermal CO2 Laser Therapy (NTCLT): A Novel Photobiomodulative Approach for Immediate Pain Relief of Patchy Oral Mucositis Due to Chemotherapy of Solid Tumors.Journal of lasers in medical sciences · 2023Article
- Effects of Photobiomodulation on Oral Mucositis: Visualization and Analysis of Knowledge.Life (Basel, Switzerland) · 2022Review
- Impact of photobiomodulation for oral mucositis on body weight and BMI of patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Classification of oral salivary gland tumors based on texture features in optical coherence tomography images.Lasers in medical science · 2022Article
- Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Laser Therapy as a Preventive Approach for Oral Mucositis in Cancer Patients Undergoing Chemotherapy: The Potential Role of Superoxide Dismutase.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Safety, Precautions, and Modalities in Cancer Rehabilitation: an Updated Review.Current physical medicine and rehabilitation reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Review effectiveness of low-level laser therapy (LLLT) in the curative treatment of oral mucositis (OM) in patients receiving cancer therapy. A systematic review with meta-analysis was performed using Medline, Embase, and Cochrane Library databases according to PRISMA guidelines, to identify randomized controlled trials (RCT) on OM in patients during and/or after cancer therapy and in which the therapeutic approach was LLLT, with wavelengths between 632 and 970 nm. We considered grade of OM as a dichotomous variable (such as an improvement or not in severe OM on the seventh day of therapy), with the analysis of subgroups of adult patients or children and adolescents and as a continuous variable with determination of the time for the complete resolution and the subgroup analysis occurred with the strata of the samples by treatment only with chemotherapy or chemotherapy and radiotherapy. This paper's protocol was registered a priori at https://www.crd.york.ac.uk/PROSPERO . We found five RCT (total of 315 patients) with adequate methodology. LLLT was effective, presenting a 62% risk reduction of severe mucositis on the seventh day of evaluation (RR = 0.38 [95% CI, 0.19-0.75]). When we analyzed subgroups, RR was 0.28 (95% CI 0.17-0.46) in the adult studies and 0.90 (95% CI, 0.46-1.78) in the studies with children and adolescents. We demonstrated a mean reduction of 4.21 days in the time of complete resolution of OM (CI - 5.65 to - 2.76) in favor of LLLT. There is moderate evidence that LLLT is effective in resolving OM lesions in adult patients undergoing cancer therapy. LLLT demonstrates potential for decreasing the resolution time of OM lesions by approximately 4.21 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.