Evidence map›Paper›PMID 30729345›Full record

ArticleClinical oral investigations2019

Correlation of magnetic resonance imaging grades with cytokine levels of synovial fluid of patients with temporomandibular joint disorders: a cross-sectional study.

Mu-Chen Yang, Ding-Han Wang, Hung-Ta Wu, Wan-Chun Li, Tsai-Yu Chang, Wen-Liang Lo, Ming-Lun Hsu

Abstract read
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Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mu-Chen YangDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan.
Ding-Han WangDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan.
Hung-Ta WuDepartment of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-pai Road, Taipei, 11217, Taiwan.
Wan-Chun LiDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan.
Tsai-Yu ChangDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan.
Wen-Liang LoDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan. wllo@vghtpe.gov.tw.
Ming-Lun HsuDepartment of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan. mlhsu@ym.edu.tw.ORCID http://orcid.org/0000-0001-6753-0485
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST105-2314-B-010-031-MY2
6 · The paper itself

Abstract

objectivesMagnetic resonance imaging (MRI) is a standardized method for assisting joint diagnosis. To validate the reliability of different imaging-based grading systems, this study examined (1) the associations between grading systems for osseous change, joint effusion, and the Wilkes classification of temporomandibular joint (TMJ) disorders and (2) the correlation between cytokines in synovial fluid and imaging-based joint scores. MATERIALS AND

methodsTwenty-seven patients, who routinely received numeric rating scale (NRS) and MRI assessment before TMJ arthrocentesis, were enrolled. Each joint was evaluated through the grading criteria for severity of osseous change and joint effusion by blinded observers using MRI. ImageJ was employed for classifying joint effusion. Joint synovial fluid, collected through arthrocentesis, was examined for cytokine expression by using a Luminex multiplex assay. All data were analyzed using the Pearson correlation analysis.

resultsThe Wilkes classification was strongly correlated with osseous change scores, but not with joint effusion scores. Joint effusion scores significantly correlated with NRS scores, but not with the Wilkes classification and osseous change scores. Compared with osseous change scores, joint effusion scores had a higher correlation with the levels of inflammatory cytokines (interleukin (IL)-8 and soluble IL-6 receptor (sIL-6R)) and with anti-inflammatory cytokines (soluble tumor necrosis factor receptors I and II (sTNF-RI/II)).

conclusionsIn patients with TMJ disorders, MRI grades are strongly correlated with NRS scores and levels of cytokines (IL-8, sIL-6R, and sTNF-RI/II) in the synovial fluid. CLINICAL RELEVANCE: Joint effusion scoring can be a reliable and valid indicator for pathological assessment of TMJ disorders.

Indexed as

AdultAgedCross-Sectional StudiesCytokinesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSynovial FluidTemporomandibular JointTemporomandibular Joint DisordersYoung AdultCytokinesCytokinesJoint effusionMagnetic resonance imagingTemporomandibular joint

Identifiers

PMID30729345
OpenAlexW2914962312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.