Evidence map›Paper›PMID 30729254›Full record

ArticleCellular and molecular life sciences : CMLS2019

Alternative polyadenylation coordinates embryonic development, sexual dimorphism and longitudinal growth in Xenopus tropicalis.

Xiang Zhou, Yangzi Zhang, Jennifer J Michal, Lujiang Qu, Shuwen Zhang, Mark R Wildung, Weiwei Du, Derek J Pouchnik, Hui Zhao, Yin Xia and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. RNA variation as the driver of genomic efficiency and phenotypic complexity.International journal of biological sciences · 2026
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  9. Genome-to-phenome research in rats: progress and perspectives.International journal of biological sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Xiang ZhouDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA.
Yangzi ZhangDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA.
Jennifer J MichalDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA.
Lujiang QuDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA.
Shuwen ZhangDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA.
Mark R WildungLaboratory for Biotechnology and Bioanalysis, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
Weiwei DuLaboratory for Biotechnology and Bioanalysis, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
Derek J PouchnikLaboratory for Biotechnology and Bioanalysis, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
Hui ZhaoSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Yin XiaSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Honghua ShiState Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai, China.
Guoli JiDepartment of Automation, Xiamen University, Xiamen, China.
Jon F DavisDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Gary D SmithDepartments of OB/GYN, Physiology, and Urology, University of Michigan, Ann Arbor, MI, USA.
Michael D GriswoldLaboratory for Biotechnology and Bioanalysis, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
Richard M HarlandDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Zhihua JiangDepartment of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164-7620, USA. jiangz@wsu.edu.ORCID http://orcid.org/0000-0003-1986-088X
Washington State University · USChinese University of Hong Kong · HKChina Agricultural University · CNEast China Normal University · CNHuazhong Agricultural University · CNUniversity of California, Berkeley · USUniversity of Michigan · USXiamen University · CN

Funding

Standardized Next Generation Transcriptome Profiling Tools for X. TropicalisR21HD076845 · NICHD · WASHINGTON STATE UNIVERSITY · PI JIANG, ZHIHUA · 2013 to 2014
$396k
National Institute of Child Health and Human Development R21 HD076845National Institute of Food and Agriculture 2016-67015-24470National Natural Science Foundation of China 61573296National Natural Science Foundation of China 61673323NICHD NIH HHS R21 HD076845
6 · The paper itself

Abstract

RNA alternative polyadenylation contributes to the complexity of information transfer from genome to phenome, thus amplifying gene function. Here, we report the first X. tropicalis resource with 127,914 alternative polyadenylation (APA) sites derived from embryos and adults. Overall, APA networks play central roles in coordinating the maternal-zygotic transition (MZT) in embryos, sexual dimorphism in adults and longitudinal growth from embryos to adults. APA sites coordinate reprogramming in embryos before the MZT, but developmental events after the MZT due to zygotic genome activation. The APA transcriptomes of young adults are more variable than growing adults and male frog APA transcriptomes are more divergent than females. The APA profiles of young females were similar to embryos before the MZT. Enriched pathways in developing embryos were distinct across the MZT and noticeably segregated from adults. Briefly, our results suggest that the minimal functional units in genomes are alternative transcripts as opposed to genes.

Indexed as

GenomeSex CharacteristicsTranscriptomeAmphibian ProteinsAnimalsEmbryonic DevelopmentEmbryo, NonmammalianExome SequencingFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene OntologyMaleMolecular Sequence AnnotationPolyadenylationRNA, MessengerAmphibian ProteinsRNA, MessengerAPA site typesGene biotypesGenomic neighborhoodsRNA originWhole transcriptome termini site sequencing (WTTS-seq)

Identifiers

PMID30729254
PMCPMC6597005
OpenAlexW2913820227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.