Evidence map›Paper›PMID 30729204›Full record

ArticleJournal of veterinary research2018

Early Cytokine Response After Vaccination with

Joanna Małaczewska, Edyta Kaczorek-Łukowska, Monika Szymańska-Czerwińska, Wojciech Rękawek, Roman Wójcik, Krzysztof Niemczuk, Andrzej Krzysztof Siwicki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Recent Advances on the Innate Immune Response toFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joanna MałaczewskaDepartment of Microbiology and Clinical Immunology, cracow, Poland.
Edyta Kaczorek-ŁukowskaDepartment of Microbiology and Clinical Immunology, cracow, Poland.
Monika Szymańska-CzerwińskaDepartment of Cattle and Sheep Diseases/Laboratory of Serological Diagnosis, National Veterinary Research Institute, 24-100, Pulawy, Poland.
Wojciech RękawekDepartment of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-718, Olsztyn, Poland.
Roman WójcikDepartment of Microbiology and Clinical Immunology, cracow, Poland.
Krzysztof NiemczukDepartment of Cattle and Sheep Diseases/Laboratory of Serological Diagnosis, National Veterinary Research Institute, 24-100, Pulawy, Poland.
Andrzej Krzysztof SiwickiDepartment of Microbiology and Clinical Immunology, cracow, Poland.
University of Warmia and Mazury in Olsztyn · PLNational Veterinary Research Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMATERIAL AND

methodsThe purpose of this research was to determine the levels of the cytokines that play a key role in the response to

resultsThe vaccination of animals did not affect the production of IL-6, IL-1β, or IL-2. The serum levels of these cytokines were too low to measure in most of the samples. The initial levels of TNFα, IFNγ, and IL-10 were higher in seropositive than in seronegative animals, although significant differences between seropositive shedders and seropositive nonshedders appeared only in the levels of IFNγ and IL-10. Additionally, the course of the post-vaccination response concerning these two cytokines was different among seronegative nonshedders, seropositive nonshedders, and seropositive shedders.

conclusionIt seems that analysis of the IFNγ and IL-10 concentrations in animal blood serum may have some practical value in an assessment of the health status of seropositive animals and post-vaccination response.

Indexed as

Coxiella burnetiicytokinesdairy cattlevaccine

Identifiers

PMID30729204
PMCPMC6364170
OpenAlexW2909234764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.