Evidence map›Paper›PMID 30729162›Full record

ArticleScience advances2019

Mitochondria-encoded genes contribute to evolution of heat and cold tolerance in yeast.

Xueying C Li, David Peris, Chris Todd Hittinger, Elaine A Sia, Justin C Fay

Abstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Deconstruction ofbioRxiv : the preprint server for biology · 2026
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  13. The evolution of thermal performance curves in response to rising temperatures across the model genus yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xueying C LiMolecular Genetics and Genomics Program, Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-1100-4694
David PerisLaboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Genome Center of Wisconsin, Wisconsin Energy Institute, J. F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-9912-8802
Chris Todd HittingerLaboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Genome Center of Wisconsin, Wisconsin Energy Institute, J. F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-5088-7461
Elaine A SiaDepartment of Biology, University of Rochester, Rochester, NY 14627, USA.ORCID 0000-0002-9934-5468
Justin C FayDepartment of Genetics, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-1893-877X

Funding

Genetic basis and evolution of thermotolerance in the Saccharomyces yeast speciesR01GM080669 · NIGMS · WASHINGTON UNIVERSITY · PI FAY, JUSTIN C · 2007 to 2025
$5.3M
NIGMS NIH HHS R01 GM080669
6 · The paper itself

Abstract

Genetic analysis of phenotypic differences between species is typically limited to interfertile species. Here, we conducted a genome-wide noncomplementation screen to identify genes that contribute to a major difference in thermal growth profile between two reproductively isolated yeast species,

Indexed as

Evolution, MolecularGenes, MitochondrialGenome, MitochondrialAllelesBase SequenceCold TemperatureDNA, MitochondrialElectron Transport Complex IVHot TemperaturePhenotypeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThermotoleranceCox1 protein, S cerevisiaeDNA, MitochondrialElectron Transport Complex IVSaccharomyces cerevisiae Proteins

Identifiers

PMID30729162
PMCPMC6353624

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.