Evidence map›Paper›PMID 30729096›Full record

ArticleFrontiers in oncology2019

Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment.

Xuefei Li, Mohit Kumar Jolly, Jason T George, Kenneth J Pienta, Herbert Levine

Abstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  19. Journal of biosciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuefei LiCenter for Theoretical Biological Physics, Rice University, Houston, TX, United States.
Mohit Kumar JollyCenter for Theoretical Biological Physics, Rice University, Houston, TX, United States.
Jason T GeorgeCenter for Theoretical Biological Physics, Rice University, Houston, TX, United States.
Kenneth J PientaThe James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Herbert LevineCenter for Theoretical Biological Physics, Rice University, Houston, TX, United States.

Funding

Co-Evolution of the CD8+ T Cell Repertoire and AML In the Setting of ImmunotherapyF30CA213878 · NCI · RICE UNIVERSITY · PI GEORGE, JASON · 2017 to 2020
$174k
NCI NIH HHS F30 CA213878
6 · The paper itself

Abstract

Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both cancer cells and different immune cells can display phenotypic plasticity in response to these communicating signals, thereby leading to complex spatiotemporal patterns that can impact therapeutic response. Here, we investigate the crosstalk between cancer cells and macrophages in a tumor microenvironment through

Indexed as

EMT–epithelial-to-mesenchymal transitioninteraction networkM1-/M2-polarized macrophagesMET–mesenchymal-to-epithelial transitionmulti-stability

Identifiers

PMID30729096
PMCPMC6351454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.