Evidence map›Paper›PMID 30729081›Full record

Review3 Biotech2019

Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics.

Kuldeep Mahato, Sahil Nagpal, Mahero Ayesha Shah, Ananya Srivastava, Pawan Kumar Maurya, Shounak Roy, Amit Jaiswal, Renu Singh, Pranjal Chandra

Abstract readReview
In one paragraph

Review in 3 Biotech, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kuldeep Mahato1Laboratory of Bio-Physio Sensors and Nanobioengineering, Department of Bioscience and Bioengineering, Indian Institute of Technology, Guwahati, Guwahati, 781039 Assam India.
Sahil Nagpal2Technische Universität Dresden, Tatzberg 47-49, 01307 Dresden, Germany.
Mahero Ayesha Shah3Julius Maximilians Universität Würzburg, Faculty of medicine Uniklinik, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Ananya Srivastava4Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, India.
Pawan Kumar Maurya5Department of Biochemistry, Central University of Haryana Mahendergarh, Haryana, 123031 India.
Shounak Roy6School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh 175001 India.
Amit Jaiswal6School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh 175001 India.
Renu Singh7Department of Bioproducts and Biosystems Engineering, University of Minnesota, Twin Cities 2004 Folwell Ave, Saint Paul, MN 55108 USA.
Pranjal Chandra1Laboratory of Bio-Physio Sensors and Nanobioengineering, Department of Bioscience and Bioengineering, Indian Institute of Technology, Guwahati, Guwahati, 781039 Assam India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) have found a wide range of biomedical and environmental monitoring applications (viz. drug delivery, diagnostics, biosensing, bio-imaging, theranostics, and hazardous chemical sensing) due to their excellent optoelectronic and enhanced physico-chemical properties. The modulation of these properties is done by functionalizing them with the synthesized AuNPs with polymers, surfactants, ligands, drugs, proteins, peptides, or oligonucleotides for attaining the target specificity, selectivity and sensitivity for their various applications in diagnostics, prognostics, and therapeutics. This review intends to highlight the contribution of such AuNPs in state-of-the-art ventures of diverse biomedical applications. Therefore, a brief discussion on the synthesis of AuNPs has been summarized prior to comprehensive detailing of their surface modification strategies and the applications. Here in, we have discussed various ways of AuNPs functionalization including thiol, phosphene, amine, polymer and silica mediated passivation strategies. Thereafter, the implications of these passivated AuNPs in sensing, surface-enhanced Raman spectroscopy (SERS), bioimaging, drug delivery, and theranostics have been extensively discussed with the a number of illustrations.

Indexed as

Biomedical applicationsGold nanoparticlesSurface functionalization strategiesSynthesis approaches

Identifiers

PMID30729081
PMCPMC6352626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.