ArticleMultiple sclerosis journal - experimental, translational and clinical
Cognitive function predicts work disability among multiple sclerosis patients.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of the Socioeconomic Consequences in Patients With Multiple Sclerosis With Different Levels of Disability and Cognitive Function.Frontiers in neurology · 2021Pooled it
- Employment status and self-rated health in people with multiple sclerosis in Sweden.BMC neurology · 2026Article
- Synaptic Density in Multiple Sclerosis: An In Vivo Study Using [Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Observational Study.JMIR human factors · 2025Observational
- Working capacity level defines the specific impairment profile of the comprehensive ICF core set for multiple sclerosis.Scientific reports · 2025Article
- Brief international cognitive assessment for MS (BICAMS) and NEDA maintenance in MS patients: A 2-year follow-up longitudinal study.European journal of neurology · 2025Article
- The relationship between work difficulties and physical disability, cognitive and social cognitive impairment and subcortical gray matter atrophy in persons with multiple sclerosis.Acta neurologica Belgica · 2024Article
- Can International Classification of Functioning, Disability and Health (ICF) Be Used for Prediction of Work Capacity and Employment Status in Multiple Sclerosis?Journal of clinical medicine · 2024Article
- Comparative effectiveness of natalizumab on cognition in multiple sclerosis: A cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Vascular comorbidity is associated with decreased cognitive functioning in inflammatory bowel disease.Scientific reports · 2023Article
- The TRACK-MS Test Battery: A Very Brief Tool to Track Multiple Sclerosis-Related Cognitive Impairment.Biomedicines · 2022Article
- A multiple sclerosis disease progression measure based on cumulative disability.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Subjective cognitive complaints and permanent work disability: a prospective cohort study.International archives of occupational and environmental health · 2021Article
- Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development.Frontiers in neurology · 2021Review
- A Pilot Study to Explore Patient Satisfaction With a Virtual Rehabilitation Program in Multiple Sclerosis: The RehabVR Study Protocol.Frontiers in neurology · 2020Article
- Cognitive functioning as a predictor of employment status in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Observational
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- Feasibility of a registry-integrated eHealth program for managing fatigue and cognitive problems in multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn multiple sclerosis various aspects of cognitive function can be detrimentally affected. More than that, patients´ employment and social functioning is likely to be impacted.
objectiveTo determine whether work disability among multiple sclerosis patients could be predicted by the symbol digit modalities test.
methodsA register-based cohort study was conducted. Individual data on work disability, operationalised as annual net days of sickness absence and/or disability pension were retrieved at baseline, when the symbol digit modalities test was performed, after one-year and 3-year follow-up for 903 multiple sclerosis patients. The incidence rate ratios for work disability were calculated with general estimating equations using a negative binomial distribution and were adjusted for gender, age, educational level, family composition, type of living area and physical disability.
resultsAfter one year of follow-up, the patients in the lowest symbol digit modalities test quartile were estimated to have a 73% higher rate of work disability when compared to the patients in the highest symbol digit modalities test quartile (incidence rate ratio 1.73, 95% confidence interval 1.42‒2.10). This estimate after 3-year follow-up was similar (incidence rate ratio 1.68, 95% confidence interval 1.40‒2.02).
conclusionCognitive function is to a high extent associated with multiple sclerosis patients' future work disability, even after adjusting for other factors.
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