ArticleLight, science & applications2019
Transmission-reflection optoacoustic ultrasound (TROPUS) computed tomography of small animals.
Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Robust automated three-dimensional speed-of-sound compensation for hemispherical photoacoustic computed tomography.Photoacoustics · 2026Article
- OpenQPAIData: Measurements of test objects with reference labels for quantitative photoacoustic imaging research.Scientific data · 2026Article
- Three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT).Science advances · 2026Article
- Data-driven super-resolution optoacoustic imaging via physically encoded signal acquisition.Research square · 2026Article
- End-to-end hardware modeling and sensitivity optimization of photoacoustic signal readout chains.Biomedical optics express · 2026Article
- Ultrasound-guided sound speed correction for photoacoustic computed tomography.Photoacoustics · 2026Article
- Neural networks for faster laser ultrasound tomography in tissue phantoms.Photoacoustics · 2026Article
- A Deep Transfer Learning Framework for Speed-of-Sound Aberration Correction in Full-Ring Photoacoustic Tomography.Sensors (Basel, Switzerland) · 2026Article
- Unified linear-concave transducer enabling 100 Hz plane-wave ultrasound and photoacoustic dynamic imaging.Biomedical optics express · 2025Article
- Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).Nature communications · 2025Article
- Reconstructing multiple initial pressure and speed of sound distributions simultaneously in photoacoustic tomography.Photoacoustics · 2025Article
- Artifacts in photoacoustic imaging: Origins and mitigations.Photoacoustics · 2025Article
- All-optical optoacoustics for clinical diagnostics.Nature biomedical engineering · 2025Article
- LED-based optoacoustic tomography of mice.Journal of biomedical optics · 2025Article
- Three-dimensional diffractive acoustic tomography.Nature communications · 2025Article
- Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2025Article
- A Deep Learning-Based Approach to Characterize Skull Physical Properties: A Phantom Study.Journal of biophotonics · 2025Article
- Learning-based sound speed estimation and aberration correction for linear-array photoacoustic imaging.Photoacoustics · 2024Article
- Challenges and advances in two-dimensional photoacoustic computed tomography: a review.Journal of biomedical optics · 2024Review
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Rapid progress in the development of multispectral optoacoustic tomography techniques has enabled unprecedented insights into biological dynamics and molecular processes in vivo and noninvasively at penetration and spatiotemporal scales not covered by modern optical microscopy methods. Ultrasound imaging provides highly complementary information on elastic and functional tissue properties and further aids in enhancing optoacoustic image quality. We devised the first hybrid transmission-reflection optoacoustic ultrasound (TROPUS) small animal imaging platform that combines optoacoustic tomography with both reflection- and transmission-mode ultrasound computed tomography. The system features full-view cross-sectional tomographic imaging geometry for concomitant noninvasive mapping of the absorbed optical energy, acoustic reflectivity, speed of sound, and acoustic attenuation in whole live mice with submillimeter resolution and unrivaled image quality. Graphics-processing unit (GPU)-based algorithms employing spatial compounding and bent-ray-tracing iterative reconstruction were further developed to attain real-time rendering of ultrasound tomography images in the full-ring acquisition geometry. In vivo mouse imaging experiments revealed fine details on the organ parenchyma, vascularization, tissue reflectivity, density, and stiffness. We further used the speed of sound maps retrieved by the transmission ultrasound tomography to improve optoacoustic reconstructions via two-compartment modeling. The newly developed synergistic multimodal combination offers unmatched capabilities for imaging multiple tissue properties and biomarkers with high resolution, penetration, and contrast.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.